This collection includes radial component displacement seismograms in the time window including the SKS, SKKS and SPdKS seismic arrivals. These data all interact with ultra-low velocity zone (ULVZ) structures at the core-mantle boundary beneath East Asia. Data used in the study of Festin et al., 2024 (TSR) is included in this collection.
Datasets include interviews and observations of healthcare staff in 25 long-term care facilities across 7 states and two data collection visits to understand frequency, type, and reason (i.e., types of care activities provided during an interaction) for staff-resident interactions in 2019 and 2020. Staff-resident interactions were studied to examine potential for multidrug-resistant organism (MDRO) transmission within long-term care settings.
This dataset accounts for all jobs undertaken by the Société Le Roy Bouillon, a funerary monuments company in Paris, from 1890 to 1902. The first sheet, “Activity Data” accounts for each job and the fee charged to the client for that job. It also categories each job as either a new cemetery construction, maintenance to existing cemetery structures, or other jobs unrelated to cemetery construction. The second sheet, “Outside Paris,” summarizes the annual activity, recording the number of projects undertaken within Paris versus outside of the city, new constructions versus maintenance work, and revenue coming in from each type of job. The original records are currently housed in a private collection in Paris and were manually transcribed by the author.
This dataset accompanies the research article entitled, "Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and its Implications for Computational Modeling of Electrical Conduction," where we quantified fibrosis and performed electrophysiological simulation to investigate electrical propagation in etiologically varied heart failure tissue samples. Included are raw confocal microscopic images, data for extracting and processing the raw images and script to analyze fibrosis and generate meshes for simulation.
This dataset encompasses the valid, completed, and qualitative data collected during the 2021 “Survey of Anime Convention Attendance in Response to Covid-19.” This survey was distributed online through social media platforms, community spaces, and industry listservs/resources in order to reach organizers, attendees, and fans of anime conventions (i.e., “cons”). The survey was intended to discover how those who attend anime conventions (i.e., "con-goers") have been experiencing changes in the anime convention scene during the COVID-19 pandemic, particularly in 2020-2021. Traditionally, anime cons and con-related activities such as cosplay (dressing up as a favorite character) are held in person. However, in 2020-2021, most cons have been cancelled or moved online; this is the first time in over 40 years, in the US and worldwide, that the anime convention scene has been so quiet. With this survey, investigators sought to capture firsthand impressions of this unprecedented moment, learning how con-goers were experiencing these changes and whether they had safety or other concerns about anime cons returning in late 2021 and early 2022.
This dataset summarizes burial counts according to burial type (free, temporary, or perpetual) for the cemeteries of Père-Lachaise, Montmartre, and Montparnasse in Paris. The data covers the period of 1804 to 1840 and was derived from the digitized daily records of burial for the city of Paris, which are currently held in the Archives de Paris. See Registres journaliers d'inhumation https://archives.paris.fr/r/216/cimetieres). These data are organized by the number of each burial type recorded per page of the digitized records.
We determined whether a large, multi-analyte panel of circulating biomarkers can improve detection of early-stage pancreatic ductal adenocarcinoma (PDAC). We defined a biologically relevant subspace of blood analytes based on previous identification in premalignant lesions or early-stage PDAC and evaluated each in pilot studies. The 31 analytes that met minimum diagnostic accuracy were measured in serum of 837 subjects (461 healthy, 194 benign pancreatic disease, 182 early stage PDAC). We used machine learning to develop classification algorithms using the relationship between subjects based on their changes across the predictors. Model performance was subsequently evaluated in an independent validation data set from 186 additional subjects.
Significance: Current medical imaging systems have many limitations for applications in cardiovascular diseases. New technologies may overcome these limitations. Particularly interesting are technologies for diagnosis of cardiac diseases, e.g. fibrosis, myocarditis, and transplant rejection.
Aim: To introduce and assess a new optical system capable of assessing cardiac muscle tissue using light-scattering spectroscopy (LSS) in conjunction with machine learning.
Approach: We applied an ovine model to investigate if the new LSS system is capable of estimating densities of cell nuclei in cardiac tissue. We measured the nuclear density using fluorescent labeling, confocal microscopy, and image processing. Spectra acquired from the same cardiac tissues were analyzed with spectral clustering and convolutional neural networks to assess feasibility and reliability of density quantification.
Results: Spectral clustering revealed distinct groups of spectra correlated to ranges of nuclear density. Convolutional neural networks correctly classified 3 groups of spectra with low, medium, or high nuclear density with 95.00±11.77% (mean and standard deviation) accuracy. The analysis revealed sensitivity of the accuracy to wavelength range and subsampling of spectra.
Conclusions: LSS and machine learning are capable of assessing nuclear density in cardiac tissues. The approach could be useful for diagnosis of cardiac diseases associated with an increase of nuclei.
Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.
This dataset is a custom Kraken2 formatted database for the identification of Fungi from shotgun metagenomic data. Kraken2 is a k-mer based read classifier (Wood et al. 2019; https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1891-0). The dataset was built with the default k-mer length (k=35) from all publicly available fungal genomes at JGI Mycocosm ( https://mycocosm.jgi.doe.gov/mycocosm/home), and all archaea, bacteria, viral, plasmid, human, fungi, plant, and protozoa genomes, as well as the UniVec Core and nt reference database at NCBI ( https://www.ncbi.nlm.nih.gov/). The reference genomes and sequences were downloaded from JGI and NCBI in March 2020.