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- Description:
- We determined whether a large, multi-analyte panel of circulating biomarkers can improve detection of early-stage pancreatic ductal adenocarcinoma (PDAC). We defined a biologically relevant subspace of blood analytes based on previous identification in premalignant lesions or early-stage PDAC and evaluated each in pilot studies. The 31 analytes that met minimum diagnostic accuracy were measured in serum of 837 subjects (461 healthy, 194 benign pancreatic disease, 182 early stage PDAC). We used machine learning to develop classification algorithms using the relationship between subjects based on their changes across the predictors. Model performance was subsequently evaluated in an independent validation data set from 186 additional subjects.
- Keyword:
- serum, pancreatic cancer, PDAC, ELISA, early stage, and bio marker
- Subject:
- medicine
- Creator:
- Firpo, Matthew A.
- Owner:
- MATTHEW FIRPO
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 01/13/2023
- Date Modified:
- 12/04/2023
- Date Created:
- 2005-01-01-2019-01-31
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
-
- Description:
- This dataset accompanies the research article entitled, "Ground Motion Amplification at Natural Rock Arches in the Colorado Plateau ," where we analyzed 13 sandstone arches in Utah, computing site-to-reference spectral amplitude ratios from continuous ambient seismic data and comparing these to spectral ratios during earthquakes and teleseismic activity. Included in this dataset are the arch vibration data.
- Keyword:
- earthquakes, geology, rock arches, spectral amplification , environmental seismology, and Utah
- Subject:
- seismology and geology
- Creator:
- Bessette-Kirton, Erin K., Finnegan, Riley, Dzubay, Alex, Moore, Jeffrey R., and Geimer, Paul R.
- Owner:
- Riley Finnegan
- Based Near Label Tesim:
- Utah, Utah, United States
- Language:
- English
- Date Uploaded:
- 04/07/2022
- Date Modified:
- 12/06/2023
- Date Created:
- 2015–01-01 to 2021-12-31
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
-
- Description:
- The similar orbital distances and incidence rates of debris disks and the prominent rings observed in protoplanetary disks suggest a potential connection between these structures. We explore this connection with new calculations that follow the evolution of rings of pebbles and planetesimals as they grow into planets and generate dusty debris. Depending on the initial solid mass and planetesimal formation efficiency, the calculations predict diverse outcomes for the resulting planet masses and accompanying debris signature. When compared with debris disk incidence rates as a function of luminosity and time, the model results indicate that the known population of bright cold debris disks can be explained by rings of solids with the (high) initial masses inferred for protoplanetary disk rings and modest planetesimal formation efficiencies that are consistent with current theories of planetesimal formation. These results support the possibility that large protoplanetary disk rings evolve into the known cold debris disks. The inferred strong evolutionary connection between protoplanetary disks with large rings and mature stars with cold debris disks implies that the remaining majority population of low-mass stars with compact protoplanetary disks leave behind only modest masses of residual solids at large radii and evolve primarily into mature stars without detectable debris beyond 30 au. The approach outlined here illustrates how combining observations with detailed evolutionary models of solids strongly constrains the global evolution of disk solids and underlying physical parameters such as the efficiency of planetesimal formation and the possible existence of invisible reservoirs of solids in protoplanetary disks.
- Keyword:
- model, low-mass stars, debris disks, planetesimals, protoplanetary disks, ring of pebbles, and planet formation
- Subject:
- Astronomy
- Creator:
- Kenyon, Scott, Najita, Joan, and Bromley, Ben
- Owner:
- BENJAMIN BROMLEY
- Based Near Label Tesim:
- Goddard, Maryland, United States
- Language:
- English
- Date Uploaded:
- 10/01/2021
- Date Modified:
- 12/06/2023
- Date Created:
- 2020-06-01 to 2021-09-28
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
-
- Description:
- The objective of this study was to determine the influence of face shields on the concentration of respirable aerosols in the breathing zone of the wearer. The experimental approach involved the generation of poly-dispersed respirable test dust aerosol in a low-speed wind tunnel over 15 minutes, with a downstream breathing mannequin. Aerosol concentrations were measured in the breathing zone of the mannequin and at an upstream location using two laser spectrophotometers that measured particle number concentration over the range 0.25-31 µm. Three face shield designs were tested (A, B and C), and were positioned on the mannequin operated at a high and low breathing rate. Efficiency – the reduction in aerosol concentration in the breathing zone – was calculated as a function of particle size and overall, for each face shield. Face shield A, a bucket hat with flexible shield, had the highest efficiency, approximately 95%, while more traditional face shield designs had efficiency 53-78%, depending on face shield and breathing rate. Efficiency varied by particle size, but the pattern differed among face shield designs. Face shields decreased the concentration of respirable aerosols in the breathing zone, when aerosols were carried perpendicular to the face. Additional research is needed to understand the impact of face shield position relative to the source.
- Keyword:
- wind tunnel, aerosols, face shield, breathing zone, breathing rate, mannequin, infection prevention, and particle size
- Subject:
- Medicine
- Creator:
- Sleeth, Darrah K., Jones, Rachael M., and Woodfield, Marion J.
- Owner:
- Rachael Jones
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 09/03/2021
- Date Modified:
- 12/08/2023
- Date Created:
- 2020-08-13 to 2020-11-10
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset