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Pharmacokinetics of Locally Delivered Vancomycin to Bone

Description:

Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.

Keyword:

pharmacokinetics, tibia, infections, systematic toxicity, bone, antibiotics, rat, osteomyelitis, and vancomycin

Subject:

Infectious Diseases

Creator:

Loc-Carrillo, Catherine

Contributor:

Wu, Sijia, Fernandez, Sheena, Burr, Michael, Fredricksen, Hunter, Canden, Ahranee, Hoerger, Kelly, Churchill, John, Wang, Caroline, and Agarwal, Jay

Owner:

BRIAN MCBRIDE

Based Near Label Tesim:

Salt Lake City, Utah, United States

Language:

English

Date Uploaded:

07/10/2019

Date Modified:

04/16/2024

Date Created:

2013-05-01 to 2015-01-30

License:

CC BY NC - Allows others to use and share your data non-commercially and with attribution.

Resource Type:

Dataset

Identifier:

https://doi.org/10.7278/S5W0942B

Pharmacokinetics of Locally Delivered Vancomycin to Bone

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