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- Description:
- Background. Common cold viruses create significant health and financial burdens, and understanding key loci of transmission would help focus control strategies. This study (1) examines factors that influence when individuals transition from a negative to positive test (acquisition) or a positive to negative test (loss) of rhinovirus (HRV) and other respiratory tract viruses in 26 households followed weekly for one year, (2) investigates evidence for intrahousehold and interhousehold transmission and the characteristics of individuals implicated in transmission, and (3) builds data-based simulation models to identify factors that most strongly affect patterns of prevalence. Methods. We detected HRV, coronavirus, paramyxovirus, influenza and bocavirus with the FilmArray polymerase chain reaction (PCR) platform (BioFire Diagnostics, LLC). We used logistic regression to find covariates affecting acquisition or loss of HRV including demographic characteristics of individuals, their household, their current infection status, and prevalence within their household and across the population. We apply generalized linear mixed models to test robustness of results. Results. Acquisition of HRV was less probable in older individuals and those infected with a coronavirus, and higher with a higher proportion of other household members infected. Loss of HRV is reduced with a higher proportion of other household members infected. Within households, only children and symptomatic individuals show evidence for transmission, while between households only a higher number of infected older children (ages 5-19) increases the probability of acquisition. Coronaviruses, paramyxoviruses and bocavirus also show evidence of intrahousehold transmission. Simulations show that age-dependent susceptibility and transmission have the largest effects on mean HRV prevalence. Conclusions. Children are most likely to acquire and most likely to transmit HRV both within and between households, with infectiousness concentrated in symptomatic children. Simulations predict that the spread of HRV and other respiratory tract viruses can be reduced but not eliminated by practices within the home.
- Keyword:
- longitudinal study, respiratory tract virus, Utah, respiratory disease, coronavirus, viral interactions, viral epidemiology, epidemiology, and rhinovirus
- Creator:
- Adler, Frederick R.
- Contributor:
- Pavia, Andrew, Byington, Carrie L., and Ampofo, Krow
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 07/30/2019
- Date Created:
- August 2009 - August 2010
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S5XG9P97
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- Description:
- The data set includes individual images of mouse cochleae, both scanning electron micrographs and fluorescent micrographs, used to generate aggregated data described in Ali A. Almishaal; Phayvanh P. Sjogren; Pranav D. Mathur; Elaine Hillas;Taelor Johnson; Melissa S. Price; Travis Haller; Jun Yang; Namakkal S. Rajasekaran; Matthew A. Firpo; Albert H. Park (2018) "Reactive Oxygen Species and Hearing Loss in Murine CMV Labyrinthitis".
- Keyword:
- congenital CMV, antioxidant, cytomegalovirus, cochlea, reactive oxygen species, outer hair cells, auditory brainstem response, mouse, hearing loss, distortion-product otoacoustic emissions, and herpesviridae
- Creator:
- Firpo, Matthew A.
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 07/30/2019
- Date Created:
- 04082015-11022016
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50D-D0WT-SV00
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Data for: Restitution Characteristics of His Bundle and Working Myocardium in Isolated Rabbit Hearts
- Description:
- The Purkinje system (PS) and the His bundle have been recently implicated as an important driver of the rapid activation rate after 1-2 minutes of ventricular fibrillation (VF). It is unknown whether activations during VF propagate through the His-Purkinje system to other portions of the the working myocardium (WM). Little is known about restitution characteristic differences between the His bundle and working myocardium at short cycle lengths. In this study, rabbit hearts (n=9) were isolated, Langendorff- perfused, and electromechanically uncoupled with blebbistatin (10 μM). Pacing pulses were delivered directly to the His bundle. By using standard glass microelectrodes, action potentials duration (APD) from the His bundle and WM were obtained simultaneously over a wide range of stimulation cycle lengths (CL). The global F-test indicated that the two restitution curves of the His bundle and the WM are statistically significantly different (P<0.05). Also, the APD of the His bundle was significantly shorter than that of WM throughout the whole pacing course (P<0.001). The CL at which alternans developed in the His bundle vs. the WM were shorter for the His bundle (134.2±13.1ms vs. 148.3±13.3ms, P<0.01) and 2:1 block developed at a shorter CL in the His bundle than in WM (130.0±10.0 vs. 145.6±14.2ms, P<0.01). The His bundle APD was significantly shorter than that of WM under both slow and rapid pacing rates, which suggest that there may be an excitable gap during VF and that the His bundle may conduct wavefronts from one bundle branch to the other at short cycle lengths and during VF.
- Keyword:
- ventricular fibrillation, action potential duration, cardiology, working myocardium, rabbit, restitution curve, alternans, His bundle, and microelectrode
- Creator:
- Ranjan, Ravi, Panitchob, Nuttanont, Huang, Shangwei, Huang, Liqun, Dosdall, Derek, and Hu, Nan
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 07/30/2019
- Date Created:
- 20160321 to 20160525
- License:
- CCO – As the data author, you are choosing to place your data into the public domain.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50R9MJX
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- Keyword:
- ophthalmology, retina, vitreous, adhesion, ocular, human, eye, peel test, and sheep
- Subject:
- Quantitative measurements of vitreoretinal adhesion in ovine and human subjects as a function of age and region
- Creator:
- Creveling, Christopher and Coats, Brittany
- Contributor:
- Colter, Jourdan
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 07/30/2019
- Date Created:
- data collection completed June 1, 2017
- License:
- CC BY – Allows others to use and share your data, even commercially, with attribution.
- Resource Type:
- Image, Video, and Dataset
- Identifier:
- https://doi.org/10.7278/S5BK19H3
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- Description:
- Background: The objective of this study was to evaluate the effect of utilising larger lens cubes on phacoemulsification efficiency and chatter using 3 tips of different sizes and 2 ultrasound (US) approaches. Methods: This was an in vitro laboratory study conducted at the John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, UT, USA. Porcine lens nuclei were formalin-soaked for 2 hours, then divided into either 2.0 mm or 3.0 mm cubes. 30 degree bent 19 G, 20 G, and 21 G tips were used with a continuous torsional US system; and straight 19 G, 20 G, and 21 G tips were used with a micropulse longitudinal US system. Efficiency and chatter were determined. Results: Mean phacoemulsification removal time was higher with the 3.0 mm lens cube for all US variations and tip sizes. There were statistically significant differences between the 19 G and 21 G tips with micropulse longitudinal US using the 2.0 mm lens cube and the 3.0 mm lens cube, as well as with continuous transversal US using the 2.0 mm lens cube and the 3.0 mm lens cube. There was no significant difference between 19 G and 20 G tips with either lens cube size in either US approach. However, using both US approaches, trends were identical for both lens cube sizes in which the 19 G tips performed better than the 20 G and 21 G tips. Conclusion: Regardless of lens size, the 19 G needle was the most efficient, with the fewest outliers and smallest standard deviations.
- Keyword:
- cataract, porcine, vacuum, lens size, ultrasound, and phacoemulsification
- Subject:
- ophthalmology
- Creator:
- Zaugg, Brian, Bernhisel, Ashlie A., Barlow, William R., Ramshekar, Aniket, Olson, Randall J., Heczko, Joshua B., and Pettey, Jeff H.
- Depositor:
- Susan Schulman
- Owner:
- Based Near Label Tesim:
- Salt Lake City
- Language:
- English
- Date Uploaded:
- 11/26/2019
- Date Modified:
- 11/26/2019
- Date Created:
- 20180201 - 20180204
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/doi:10.7278/S50D-ZTWP-VF00