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Data for: Restitution Characteristics of His Bundle and Working Myocardium in Isolated Rabbit Hearts
- Description:
- The Purkinje system (PS) and the His bundle have been recently implicated as an important driver of the rapid activation rate after 1-2 minutes of ventricular fibrillation (VF). It is unknown whether activations during VF propagate through the His-Purkinje system to other portions of the the working myocardium (WM). Little is known about restitution characteristic differences between the His bundle and working myocardium at short cycle lengths. In this study, rabbit hearts (n=9) were isolated, Langendorff- perfused, and electromechanically uncoupled with blebbistatin (10 μM). Pacing pulses were delivered directly to the His bundle. By using standard glass microelectrodes, action potentials duration (APD) from the His bundle and WM were obtained simultaneously over a wide range of stimulation cycle lengths (CL). The global F-test indicated that the two restitution curves of the His bundle and the WM are statistically significantly different (P<0.05). Also, the APD of the His bundle was significantly shorter than that of WM throughout the whole pacing course (P<0.001). The CL at which alternans developed in the His bundle vs. the WM were shorter for the His bundle (134.2±13.1ms vs. 148.3±13.3ms, P<0.01) and 2:1 block developed at a shorter CL in the His bundle than in WM (130.0±10.0 vs. 145.6±14.2ms, P<0.01). The His bundle APD was significantly shorter than that of WM under both slow and rapid pacing rates, which suggest that there may be an excitable gap during VF and that the His bundle may conduct wavefronts from one bundle branch to the other at short cycle lengths and during VF.
- Keyword:
- ventricular fibrillation, action potential duration, cardiology, working myocardium, rabbit, restitution curve, alternans, His bundle, and microelectrode
- Subject:
- ventricular fibrillation, cardiology, and myocardium
- Creator:
- Huang, Shangwei, Panitchob, Nuttanont, Hu, Nan, Ranjan, Ravi, Huang, Liqun, and Dosdall, Derek
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/18/2024
- Date Created:
- 2016-03-21 to 2016-05-25
- License:
- CCO – As the data author, you are choosing to place your data into the public domain.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50R9MJX
-
- Description:
- While several studies have qualitatively investigated age- and region-dependent adhesion between the vitreous and retina, no studies have directly measured the vitreoretinal strength of adhesion. In this study, we developed a rotational peel device and associated methodology to measure the maximum and steady-state peel forces between the vitreous and the retina. Vitreoretinal adhesion in the equator and posterior pole were measured in human eyes from donors ranging 30 to 79 years of age, and in sheep eyes from premature, neonatal, young lamb, and young adult sheep. In human eyes, maximum peel force in the equator (7.24 ± 4.13 mN) was greater than in the posterior pole (4.08 ± 2.03 mN). This trend was especially evident for younger eyes from donors 30 to 39 years of age. After 60 years of age, there was a significant decrease in the maximum equatorial (4.69 ± 2.52 mN, p = 0.016) and posterior pole adhesion (2.95 ± 1.25 mN, p = 0.037). In immature sheep eyes, maximum adhesion was 7.60 ± 3.06 mN, and did not significantly differ between the equator and posterior pole until young adulthood. At this age, the maximum adhesion in the equator nearly doubled (16.67 ± 7.45 mN) that of the posterior pole, similar to the young adult human eyes. Light microscopy images suggest more disruption of the inner limiting membrane (ILM) in immature sheep eyes compared to adult sheep eyes. Interestingly, in human eyes, ILM disruption was significantly greater in the posterior pole (p < 0.05) and in people over 60 years of age (p < 0.02). These findings supplement the current discussion surrounding age-related posterior vitreous detachment, and the risk factors and physiological progressions associated with this condition. In addition, these data further our understanding of the biomechanical mechanisms of vitreoretinal adhesion, and can be used to develop age- appropriate computational models simulating retinal detachment, hemorrhaging, or retinal trauma. See Creveling CJ, Colter J, Coats B. 2018. Changes in vitreoretinal adhesion with age and region in human and sheep eyes. Frontiers in Bioengineering and Biotechnology 6. https://doi.org/10.3389/fbioe.2018.00153.
- Keyword:
- ophthalmology, retina, vitreous, adhesion, ocular, human, eye, peel test, and sheep
- Subject:
- Quantitative measurement and Vitreoretinal Adhesion
- Creator:
- Coats, Brittany and Creveling, Christopher
- Contributor:
- Colter, Jourdan
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/18/2024
- Date Created:
- Completed 2017-06-01
- License:
- CC BY – Allows others to use and share your data, even commercially, with attribution.
- Resource Type:
- Image, Dataset, and Video
- Identifier:
- https://doi.org/10.7278/S5BK19H3
-
- Description:
- Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.
- Keyword:
- pharmacokinetics, tibia, infections, systematic toxicity, bone, antibiotics, rat, osteomyelitis, and vancomycin
- Subject:
- Infectious Diseases
- Creator:
- Loc-Carrillo, Catherine
- Contributor:
- Wu, Sijia, Fernandez, Sheena, Burr, Michael, Fredricksen, Hunter, Canden, Ahranee, Hoerger, Kelly, Churchill, John, Wang, Caroline, and Agarwal, Jay
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/16/2024
- Date Created:
- 2013-05-01 to 2015-01-30
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S5W0942B
-
- Description:
- This dataset provides access to data from personnel records of miner employment from 1900–1919. Records from the Utah Copper Company are handwritten and contain the following employee information: name, date employed, address, dependents, age, weight, height, eyes, hair, gender, and nationality. Data has been transcribed and released as a .tsv (Tab Separated Values) file. Technical metadata has been redacted.
- Keyword:
- mining, copper miners, Bingham Copper Mine, and labor records
- Subject:
- mining camps, miners, Bingham Copper Mine (Utah), and copper miners
- Creator:
- Neatrour, Anna and Wittmann, Rachel Jane
- Depositor:
- Kaylee Alexander
- Owner:
- ANNA NEATROUR
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 11/16/2023
- Date Modified:
- 02/01/2024
- Date Created:
- 2021-02-05
- License:
- CCO – As the data author, you are choosing to place your data into the public domain.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50d-7zxh-42hf
-
- Description:
- This dataset contains room occupancy during the study period at University of Utah hospital. Admission, Discharge, and Transfer (ADT) data is captured in participating hospitals to characterize room occupancy and non-occupancy in wards. These data are pulled from multiple sources collected during the study by study staff as well as harvested EHR data. Data were adjudicated and compiled into one comprehensive file. Data manipulation included redaction of dates, replaced with study days 1-n, as well as transformation from long format to wide for ease of use.
- Keyword:
- bed occupancy, transfer, discharge, ADT, and admission
- Subject:
- bed occupancy
- Creator:
- Haroldsen, Candace, Rubin, Michael, and Leecaster, Molly
- Contributor:
- Huber, Tavis and Stratford, Kristina
- Owner:
- Michael Rubin
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 12/26/2023
- Date Modified:
- 01/04/2024
- Date Created:
- 2018
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- www.doi.org/10.7278/S50d-6wz0-jk8j
-
- Description:
- The objective of using the wireless sensors was to improve understanding of the heterogeneity of healthcare worker (HCW) contact with patients and the physical environment in patients’ rooms. The framework and design were based on contact networks with a) nodes defined by HCW’s, rooms, and items in the room and b) edges defined by HCW’s in the room, near the bed, and touching items. Nodes had characteristics of HCW role and room number. Edges had characteristics of day, start time, and duration. Thus, patterns and heterogeneity could be understood within contexts of time, space, roles, and patient characteristics. At the University of Utah Hospital Cardiovascular ICU (CVICU), a 20-bed unit, we collected data for 54 days. HCW contact with patients was measured using wireless sensors to capture time spent in patient rooms as well as time spent near the patient bed. HCW contact with the physical environment was measured using wireless sensors on the following items in patient rooms: door, sink, toilet, over-bed table, keyboard, vital signs monitor touchscreen, and cart. HCW’s clipped a sensor to their clothing or lanyard. This dataset contains cleaned sensor pings of RFD reads between healthcare worker worn sensors and environmental sensors placed in facility using methods described in the "Data Cleaning Steps" section.
- Keyword:
- patient contact and wireless sensors
- Subject:
- cardiology
- Creator:
- Rubin, Michael, Haroldsen, Candace, and Leecaster, Molly
- Contributor:
- Huber, Tavis and Stratford, Kristina
- Owner:
- Michael Rubin
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 12/26/2023
- Date Modified:
- 01/04/2024
- Date Created:
- 2018
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- www.doi.org/10.7278/S50d-twbh-955q
-
- Description:
- The microbiology data represents the microorganisms recovered during the study period at the University of Utah hospital from samples collected from patients, environmental surfaces, and healthcare personnel (HCP) hands using premoistened sponges. Patient samples were collected daily from the axilla, groin, and perianal areas or stool. Environmental samples were collected daily from room surfaces and unit common areas (such as bed rails, overbed tables, door handles, computer keyboards, and other high-touch areas). HCP hands were periodically sampled upon HCP exit from a patient room after engaging in health care activities. Samples were collected from the 20-bed University of Utah Hospital Cardiovascular ICU (CVICU) over a 54 day period. The information from these datasets can be used to understand how different organisms appear and move throughout a hospital ward over a period of time.
- Keyword:
- patient sampling, microbiology, multidrug-resistant organisms, healthcare worker hand sampling, and environmental sampling
- Subject:
- microbiology
- Creator:
- Rubin, Michael , Leecaster, Molly, and Haroldsen, Candace
- Contributor:
- Kristina Stratford and Tavis Huber
- Owner:
- Michael Rubin
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 12/26/2023
- Date Modified:
- 01/04/2024
- Date Created:
- 2018-03-01 to 2018-04-28
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- http://doi.org/10.7278/S50d-n2s8-h8jk
-
- Description:
- A comprehensive geochemical and stratigraphic study of Cretaceous coal-bearing strata in Utah and western Colorado was performed to evaluate geologic trends in REE-enrichment, as well as elucidate enrichment mechanisms. Preliminary portable X-ray fluorescence (pXRF) analyses (n = 5659) was combined with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) analyses (n = 135) on particularly REE-enriched samples. Sampling and analyses from active and historic mines as well as nearby cores and outcrops were performed with an emphasis on sedimentary, stratigraphic, geographic, and mining context.
- Keyword:
- critical minerals, Cretaceous period, Mesaverde Group, rare earth elements, energy transition, Ferron Sandstone, Blackhawk Formation, Uinta region, and coal
- Subject:
- economic geology, core analysis, critical minerals , coal resources, nonmetallic mineral resources, sedimentology, and stratigraphy
- Creator:
- Birgenheier, Lauren, Fausett, Peyton, Gall, Ryan, Fernandez, Diego , Giebel, Andrew , Vanden Berg, Michael D., Morris, Emma , Wilcock, Laura , Coe, Haley , and Free, Michael
- Contributor:
- Hoskins, Brittney, Ashurst-McGee, Logan, and Bailey, Nick
- Owner:
- Based Near Label Tesim:
- Salt Lake City, Utah, United States, Uinta Basin, Utah, United States, and Piceance Creek Basin, Colorado, United States
- Language:
- English
- Date Uploaded:
- 12/14/2023
- Date Modified:
- 12/19/2023
- Date Created:
- 2022-05-23 to 2023-08-18
- License:
- Public Domain – This data is free of copyright restrictions (e.g. government sponsored data).
- Resource Type:
- Dataset
- Identifier:
- https://www.doi.org/10.7278/S50d-08s4-3d7j
-
- Description:
- This study aims to quantify rare earth element enrichment within coal and coal-adjacent strata in the Uinta Region of Utah and western Colorado. Rare earth elements are a subset of critical minerals used for renewable energy technology in the transition toward carbon-neutral energy. This data contains samples from seven active mines and seven stratigraphically complete cores within the Uinta Region, geochemically evaluated via portable X-ray fluorescence (n=3,113) and inductively coupled plasma-mass spectrometry (n=143) elemental abundance methods. Historical evaluations of geochemical data on Uinta Region coal and coal-adjacent data are sparse, emphasizing the statistical significance of this study’s analyses. These results support the utilization of active mines and coal processing waste piles for the future of domestic rare earth element extraction, offering economic and environmental solutions to pressing global demands.
- Keyword:
- Mesaverde Group, Cretaceous, coal, critical minerals, energy transition, Blackhawk Formation, Uinta Region, and rare earth elements
- Subject:
- stratigraphy, geochemistry, coal resources, sedimentology, and economic geology
- Creator:
- Birgenheier, Lauren, Coe, Haley, Gall, Ryan, Fernandez, Diego, Giebel, Andrew, Vanden Berg, Michael D., and Free, Michael
- Contributor:
- Hamidat, Amin and Starkie, Erin
- Owner:
- Based Near Label Tesim:
- Salt Lake City, Utah, United States, Uinta Basin, Utah, United States, and Piceance Creek Basin, Colorado, United States
- Language:
- English
- Date Uploaded:
- 12/14/2023
- Date Modified:
- 12/19/2023
- Date Created:
- 2022-05-23 to 2023-03-01
- License:
- Public Domain – This data is free of copyright restrictions (e.g. government sponsored data).
- Resource Type:
- Dataset
- Identifier:
- www.doi.org/10.7278/S50d-5ny1-1wc1
-
- Description:
- This dataset accompanies the research article entitled, "Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and its Implications for Computational Modeling of Electrical Conduction," where we quantified fibrosis and performed electrophysiological simulation to investigate electrical propagation in etiologically varied heart failure tissue samples. Included are raw confocal microscopic images, data for extracting and processing the raw images and script to analyze fibrosis and generate meshes for simulation.
- Keyword:
- human, heart failure, cardiac, confocal microscopic images, simulation, and fibrosis
- Subject:
- cardiology
- Creator:
- Drakos, Stavros G., Sachse, Frank B., Kyriakopoulos, Christos P., Bragard, Jean, Greiner, Joachim, Chakkalakkal Sankarankutty, Aparna, Visker, Joseph R., and Shankar, Thirupura S.
- Owner:
- Aparna Sankarankutty
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 06/08/2021
- Date Modified:
- 12/08/2023
- Date Created:
- 2019-01-01 to 2020-11-30
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50D-BPS8-R06S
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