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- Description:
- While several studies have qualitatively investigated age- and region-dependent adhesion between the vitreous and retina, no studies have directly measured the vitreoretinal strength of adhesion. In this study, we developed a rotational peel device and associated methodology to measure the maximum and steady-state peel forces between the vitreous and the retina. Vitreoretinal adhesion in the equator and posterior pole were measured in human eyes from donors ranging 30 to 79 years of age, and in sheep eyes from premature, neonatal, young lamb, and young adult sheep. In human eyes, maximum peel force in the equator (7.24 ± 4.13 mN) was greater than in the posterior pole (4.08 ± 2.03 mN). This trend was especially evident for younger eyes from donors 30 to 39 years of age. After 60 years of age, there was a significant decrease in the maximum equatorial (4.69 ± 2.52 mN, p = 0.016) and posterior pole adhesion (2.95 ± 1.25 mN, p = 0.037). In immature sheep eyes, maximum adhesion was 7.60 ± 3.06 mN, and did not significantly differ between the equator and posterior pole until young adulthood. At this age, the maximum adhesion in the equator nearly doubled (16.67 ± 7.45 mN) that of the posterior pole, similar to the young adult human eyes. Light microscopy images suggest more disruption of the inner limiting membrane (ILM) in immature sheep eyes compared to adult sheep eyes. Interestingly, in human eyes, ILM disruption was significantly greater in the posterior pole (p < 0.05) and in people over 60 years of age (p < 0.02). These findings supplement the current discussion surrounding age-related posterior vitreous detachment, and the risk factors and physiological progressions associated with this condition. In addition, these data further our understanding of the biomechanical mechanisms of vitreoretinal adhesion, and can be used to develop age- appropriate computational models simulating retinal detachment, hemorrhaging, or retinal trauma. See Creveling CJ, Colter J, Coats B. 2018. Changes in vitreoretinal adhesion with age and region in human and sheep eyes. Frontiers in Bioengineering and Biotechnology 6. https://doi.org/10.3389/fbioe.2018.00153.
- Keyword:
- ophthalmology, retina, vitreous, adhesion, ocular, human, eye, peel test, and sheep
- Subject:
- Quantitative measurement and Vitreoretinal Adhesion
- Creator:
- Coats, Brittany and Creveling, Christopher
- Contributor:
- Colter, Jourdan
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/18/2024
- Date Created:
- Completed 2017-06-01
- License:
- CC BY – Allows others to use and share your data, even commercially, with attribution.
- Resource Type:
- Image, Dataset, and Video
- Identifier:
- https://doi.org/10.7278/S5BK19H3
-
Data for: Restitution Characteristics of His Bundle and Working Myocardium in Isolated Rabbit Hearts
- Description:
- The Purkinje system (PS) and the His bundle have been recently implicated as an important driver of the rapid activation rate after 1-2 minutes of ventricular fibrillation (VF). It is unknown whether activations during VF propagate through the His-Purkinje system to other portions of the the working myocardium (WM). Little is known about restitution characteristic differences between the His bundle and working myocardium at short cycle lengths. In this study, rabbit hearts (n=9) were isolated, Langendorff- perfused, and electromechanically uncoupled with blebbistatin (10 μM). Pacing pulses were delivered directly to the His bundle. By using standard glass microelectrodes, action potentials duration (APD) from the His bundle and WM were obtained simultaneously over a wide range of stimulation cycle lengths (CL). The global F-test indicated that the two restitution curves of the His bundle and the WM are statistically significantly different (P<0.05). Also, the APD of the His bundle was significantly shorter than that of WM throughout the whole pacing course (P<0.001). The CL at which alternans developed in the His bundle vs. the WM were shorter for the His bundle (134.2±13.1ms vs. 148.3±13.3ms, P<0.01) and 2:1 block developed at a shorter CL in the His bundle than in WM (130.0±10.0 vs. 145.6±14.2ms, P<0.01). The His bundle APD was significantly shorter than that of WM under both slow and rapid pacing rates, which suggest that there may be an excitable gap during VF and that the His bundle may conduct wavefronts from one bundle branch to the other at short cycle lengths and during VF.
- Keyword:
- ventricular fibrillation, action potential duration, cardiology, working myocardium, rabbit, restitution curve, alternans, His bundle, and microelectrode
- Subject:
- ventricular fibrillation, cardiology, and myocardium
- Creator:
- Huang, Shangwei, Panitchob, Nuttanont, Hu, Nan, Ranjan, Ravi, Huang, Liqun, and Dosdall, Derek
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/18/2024
- Date Created:
- 2016-03-21 to 2016-05-25
- License:
- CCO – As the data author, you are choosing to place your data into the public domain.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50R9MJX
-
- Description:
- Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.
- Keyword:
- pharmacokinetics, tibia, infections, systematic toxicity, bone, antibiotics, rat, osteomyelitis, and vancomycin
- Subject:
- Infectious Diseases
- Creator:
- Loc-Carrillo, Catherine
- Contributor:
- Wu, Sijia, Fernandez, Sheena, Burr, Michael, Fredricksen, Hunter, Canden, Ahranee, Hoerger, Kelly, Churchill, John, Wang, Caroline, and Agarwal, Jay
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 04/16/2024
- Date Created:
- 2013-05-01 to 2015-01-30
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S5W0942B
-
- Description:
- Background. Common cold viruses create significant health and financial burdens, and understanding key loci of transmission would help focus control strategies. This study (1) examines factors that influence when individuals transition from a negative to positive test (acquisition) or a positive to negative test (loss) of rhinovirus (HRV) and other respiratory tract viruses in 26 households followed weekly for one year, (2) investigates evidence for intrahousehold and interhousehold transmission and the characteristics of individuals implicated in transmission, and (3) builds data-based simulation models to identify factors that most strongly affect patterns of prevalence. Methods. We detected HRV, coronavirus, paramyxovirus, influenza and bocavirus with the FilmArray polymerase chain reaction (PCR) platform (BioFire Diagnostics, LLC). We used logistic regression to find covariates affecting acquisition or loss of HRV including demographic characteristics of individuals, their household, their current infection status, and prevalence within their household and across the population. We apply generalized linear mixed models to test robustness of results. Results. Acquisition of HRV was less probable in older individuals and those infected with a coronavirus, and higher with a higher proportion of other household members infected. Loss of HRV is reduced with a higher proportion of other household members infected. Within households, only children and symptomatic individuals show evidence for transmission, while between households only a higher number of infected older children (ages 5-19) increases the probability of acquisition. Coronaviruses, paramyxoviruses and bocavirus also show evidence of intrahousehold transmission. Simulations show that age-dependent susceptibility and transmission have the largest effects on mean HRV prevalence. Conclusions. Children are most likely to acquire and most likely to transmit HRV both within and between households, with infectiousness concentrated in symptomatic children. Simulations predict that the spread of HRV and other respiratory tract viruses can be reduced but not eliminated by practices within the home.
- Creator:
- Adler, Frederick R.
- Contributor:
- Ampofo, Krow, Pavia, Andrew, and Byington, Carrie L.
- Owner:
- BRIAN MCBRIDE
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 07/10/2019
- Date Modified:
- 12/09/2021
- Date Created:
- August 2009 - August 2010
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S5XG9P97
-
- Description:
- This dataset provides access to data from personnel records of miner employment from 1900–1919. Records from the Utah Copper Company are handwritten and contain the following employee information: name, date employed, address, dependents, age, weight, height, eyes, hair, gender, and nationality. Data has been transcribed and released as a .tsv (Tab Separated Values) file. Technical metadata has been redacted.
- Keyword:
- mining, copper miners, Bingham Copper Mine, and labor records
- Subject:
- mining camps, miners, Bingham Copper Mine (Utah), and copper miners
- Creator:
- Neatrour, Anna and Wittmann, Rachel Jane
- Depositor:
- Kaylee Alexander
- Owner:
- ANNA NEATROUR
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 11/16/2023
- Date Modified:
- 02/01/2024
- Date Created:
- 2021-02-05
- License:
- CCO – As the data author, you are choosing to place your data into the public domain.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50d-7zxh-42hf
-
- Description:
- The data was obtained from the FDTD simulations. For one of the FDTD simulations, the conductivity data for British Columbia was used in order to obtain the simulated data. The data obtained from simulations are post-processed using MATLAB for plotting the figures in the paper.
- Keyword:
- weather hazards, space weather, electrical and computer engineering, and FDTD results
- Subject:
- electrical engineering and computation
- Creator:
- Zhang, Yisong, Sharma Paneru, Prashanna , and Simpson, Jamesina J.
- Owner:
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 02/22/2023
- Date Modified:
- 11/29/2023
- Date Created:
- 2021-05-01 to 2023-01-31
- License:
- Public Domain – This data is free of copyright restrictions (e.g. government sponsored data).
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50d-vsvt-ecjx
-
- Description:
- This is the IDL code used to create the results published in Mace, G. G., Benson, S., Humphries, R., Gombert P. M., Sterner, E.: Natural marine cloud brightening in the Southern Ocean, Atmospheric Chemistry and Physics. The IDL code processes MOD03 geolocation fields, MOD06_L2 cloud retrievals, MODIS ocean color chlorophyll-a concentrations and CERES shortwave albedo data that is distributed by NASA data archives. It creates statistical results for non-precipitating or weakly precipitating warm, liquid, shallow, marine boundary layer clouds.
- Keyword:
- MODIS, clouds, and southern ocean
- Subject:
- clouds and atmospheric boundary layer
- Creator:
- Mace, G. G., Humphries, R., Gombert, P. M., Benson, Sally, and Sterner, E.
- Owner:
- Sally Benson
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 01/09/2023
- Date Modified:
- 12/04/2023
- Date Created:
- 2020-06-01-2022-11-01
- License:
- Public Domain – This data is free of copyright restrictions (e.g. government sponsored data).
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50d-bpx8-gmtt
-
- Description:
- Abstract: Data for Performance evaluation of the Alphasense OPC-N3 and Plantower PMS5003 sensor in measuring dust events in the Salt Lake Valley, Utah This data file was used to estimate the performance of the Alphasense OPC-N3 and PMS5003 sensor in measuring ambient PM10, especially during dust events, and to obtain correction factors to correct the PMS5003 data. During April 2022, the OPC-N3 and PMS5003 sensors were collocated with federal equivalent method (FEM)at two Utah Division of Air Quality (UDAQ) sites: Hawthorne (HW) station and Environmental Quality (EQ) station. One residential site (RS)was also tested, with OPC-N3 and PMS5003 collocated with GRIMM portable aerosol spectrophotometer. The FEM data (PM2.5 and PM10 concentrations) and meteorological parameters (wind speed, wind direction, relative humidity, and temperature) for the two UDAQ sites were downloaded from the EPA website. The Excel sheet contained all the raw data and the processed data. The FEM, OPC-N3, and PMS5003 measurements were labeled as FEM-YYY, OPC-YYY, and PMS-YYY, where YYY represents the sites nomenclature, i.e., HW, EQ, and RS. The sheet labeled “HW”, “RS”, and,” EQ” contained the raw measurements (meteorological, PM10, and PM2.5 (whenever applicable)) for the sites. The sheet” PM-ratio-based correlation” provided the data used to get the PM-ratio-based correlation. Briefly, based on the ratio of FEM-HW PM2.5/PM10, the FEM-HW and PMS-HW PM10 measurements were segregated into six bins: PM2.5/PM10: <0.2, 0.2-0.3, 0.3-0.4, 0.4-0.5, 0.5-0.7, and >0.7. For each bin, the co-located PMS-HW PM10 concentrations were linearly regressed against the FEM-HW PM10 concentrations to obtain correction factors (slope and intercept). These correction factors were later used to correct the PMS PM10 concentrations at the other two locations (RS and EQ), presented in the sheets with labels “RS correction using GRIMM ratio”, “RS correction using opc ratio” and “EQ corrected using EQ ratio”. Each sheet also includes the calculation of RMSE and NRMSE of OPC-YYY and PMS-YYY against FEM-YYY, with YYY as the site nomenclature.
- Keyword:
- Plantower PMS5003, dust events, air pollution, air quality, ppticle particle counters, PM10, AQI, particulate matter, PM sensor, and Alphasense OPC-N3 performance during
- Subject:
- air pollution
- Creator:
- Kelly, Kerry and Kaur, Kamaljeet
- Owner:
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 10/20/2022
- Date Modified:
- 12/04/2023
- Date Created:
- 2022-04-01 to 2022-04-30
- License:
- CC BY – Allows others to use and share your data, even commercially, with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50d-xbns-3ge3
-
- Description:
- The dataset contains Gas Chromatography (GC) data pertaining to the bulk electrolytic experiments, biocatalytic, organocatalytic reactions, and standards used in the study. The standard GC files calibrate the sensitivity of the column in the Gas Chromatograph to 1-heptanol, heptanal, and the corresponding alpha-hydrazino aldehyde. This information is used to quantify the peaks of 1-heptanol and heptanal obtained in the bulk electrolytic experiments and the alpha-hydrazino aldehyde obtained in the organocatalytic step.
- Keyword:
- C-H activation, tandem catalysis, organocatalysis, in vitro multi enzyme cascade, hybrid bioelectrocatalysis, and redox polymer mediation
- Subject:
- Chemistry
- Creator:
- Chen, Hui, Minteer, Shelley D., Weliwatte, N. Samali, and Tang, Tianhua
- Owner:
- Samali Weliwatte
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 10/07/2022
- Date Modified:
- 12/05/2023
- Date Created:
- 2021-01-01 to 2022-12-31
- License:
- CC BY – Allows others to use and share your data, even commercially, with attribution.
- Resource Type:
- Dataset
- Identifier:
- https://doi.org/10.7278/S50d-m87v-xesj
-
- Description:
- The microbiology data represents the microorganisms recovered during the study period at the University of Utah hospital from samples collected from patients, environmental surfaces, and healthcare personnel (HCP) hands using premoistened sponges. Patient samples were collected daily from the axilla, groin, and perianal areas or stool. Environmental samples were collected daily from room surfaces and unit common areas (such as bed rails, overbed tables, door handles, computer keyboards, and other high-touch areas). HCP hands were periodically sampled upon HCP exit from a patient room after engaging in health care activities. Samples were collected from the 20-bed University of Utah Hospital Cardiovascular ICU (CVICU) over a 54 day period. The information from these datasets can be used to understand how different organisms appear and move throughout a hospital ward over a period of time.
- Keyword:
- patient sampling, microbiology, multidrug-resistant organisms, healthcare worker hand sampling, and environmental sampling
- Subject:
- microbiology
- Creator:
- Rubin, Michael , Leecaster, Molly, and Haroldsen, Candace
- Contributor:
- Kristina Stratford and Tavis Huber
- Owner:
- Michael Rubin
- Based Near Label Tesim:
- Salt Lake City, Utah, United States
- Language:
- English
- Date Uploaded:
- 12/26/2023
- Date Modified:
- 01/04/2024
- Date Created:
- 2018-03-01 to 2018-04-28
- License:
- CC BY NC - Allows others to use and share your data non-commercially and with attribution.
- Resource Type:
- Dataset
- Identifier:
- http://doi.org/10.7278/S50d-n2s8-h8jk
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