This dataset contains code used to generate and the results of 2D numerical modeling simulations of ambient resonance in damaged rock slopes. All simulations were performed using the Universal Distinct Element Code (UDEC) version 7.0. We simulated progressive damage for three different landslide types: slab toppling, flexural toppling, and planar sliding. For each scenario we simulated several stages of progressive rock slope damage. Subsequently, we recorded the resonance response of the rock slope at each stage by measuring x-direction velocity at one or more measuring points throughout the model.
This dataset contains GIS map data and monitoring datasets collected between 2018 and 2022 at the Courthouse Mesa rock slope instability near Moab, Utah. Map data consist of an orthophoto, a polyline shapefile delineating mapped surficial cracks, and a point shapefile showing the locations of crack width monitoring points (M1–M5) and a vibrating wire crackmeter. Monitoring data include four years of continuous crack aperture measurements from the crackmeter, periodic crack width measurements from M1–M5, and three sets of air temperature measurements recorded between 2018 and 2022. Air temperatures were measured at the surface and inside the crack at several depths throughout the monitoring period.
Localization of the components of the cardiac conduction system (CCS) is essential for many therapeutic procedures in cardiac surgery and interventional cardiology. While histological studies provided fundamental insights into CCS localization, this information is incomplete and difficult to translate to aid in intraprocedural localization. To advance our understanding of CCS localization, we set out to establish a framework for quantifying nodal region morphology. Using this framework, we quantitatively analyzed the sinoatrial node (SAN) and atrioventricular node (AVN) in ovine with menstrual age ranging from 4.4 to 58.3 months. In particular, we studied the SAN and AVN in relation to the epicardial and endocardial surfaces, respectively. Using anatomical landmarks, we excised the nodes and adjacent tissues, sectioned those at a thickness of 4 µm at 100 µm intervals, and applied Masson’s trichrome stain to the sections. These sections were then imaged, segmented to identify nodal tissue, and analyzed to quantify nodal depth and superficial tissue composition. The minimal SAN depth ranged between 20 and 926 µm. AVN minimal depth ranged between 59 and 1192 µm in the AVN extension region, 49 and 980 µm for the compact node, and 148 and 888 µm for the transition to His Bundle region. Using a logarithmic regression model, we found that minimal depth increased logarithmically with age for the AVN (R2=0.818, P=0.002). Also, the myocardial overlay of the AVN was heterogeneous within different regions and decreased with increasing age. Age associated alterations of SAN minimal depth were insignificant. Our study presents examples of characteristic tissue patterns superficial to the AVN and within the SAN. We suggest that the presented framework provides quantitative information for CCS localization. Our studies indicate that procedural methods and localization approaches in regions near the AVN should account for the age of patients in cardiac surgery and interventional cardiology.
-------------------------- METHODOLOGICAL INFORMATION --------------------------
1. Description of methods used for collection/generation of data: The data were generated by computer simulations using the C++ code "Orchestra", a proprietary hybrid code that follows the dynamical evolution of solids and gas orbiting a central object. Algorithms in the code are described in the following papers (author names abbreviated to B for Bromley, K for Kenyon, and L for Jane X Luu along with a year for publication date, AJ = Astronomical Journal, ApJ = Astrophysical Journal, S=Supplement): KL1998, AJ 115:2136; KL1999, AJ 118:1101; KB2001,AJ 121:538; KB2002,AJ 123:1757; KB2004, AJ 127:513; BK2006, AJ 131:2737; KB2006, AJ 131:1837; KB2008, ApJS 179:451; KB2010, ApJS 188:242; BK2011, ApJ 731:101; KB2012, AJ 143:63; KB2014, AJ 147:8. Initial conditions for these simulations described in the published paper.
2. Methods for processing the data: Various C and fortran programs are used to analyze the data for the calculations. Several C programs needed to extract information from the computer generated binary output files are included with the dataset. The C programs include basic summaries of the structure of the data files and the usage to extract data from each binary file.
3. Instrument- or software-specific information needed to interpret the data: Appropriate software is included in directory.
4. Standards and calibration information, if appropriate: none
5. Environmental/experimental conditions: all calculations were run on the NASA discover cluster
6. Describe any quality-assurance procedures performed on the data: Aside from tests summarized in the papers described in item 1, test calculations are summarized in the Appendix of each paper and compared to an appropriate benchmark.
7. People involved with sample collection, processing, analysis and/or submission: Scott Kenyon and Ben Bromley and --------------------- DATA & FILE OVERVIEW ---------------------
Files summarized in items 1-8 are binary output files from n-body simulations as described in Kenyon & Bromley, "A Pluto-Charon Sonata: Dynamical Limits on fate Masses of the Small Satellites" (2019, Astronomical Journal). Files described in item 9 are ascii txt. The C programs in items 10, 11, and 12 provide different ways to access the binary output. Each C program describes the architecture of the binary files.
1. pcs2-0mmm-nnn[a-z] files: heavy satellites, mmm = 100 x mass factor for all satellites, nnn = number of Symplectic steps per PC orbit, a-z = version
2. pcs2-1mmm-nnn[a-z] files: light satellites, mmm = 100 x mass factor for all satellites, nnn = number of Symplectic steps per PC orbit, a-z = version
3. pcs2-2mmm-nnn[a-z] files: light satellites with 2x nominal mass of Styx & Kerberos, mmm = 100 x mass factor for all satellites, nnn = number of Symplectic steps per PC orbit, a-z = version
4. pcs2-3mmm: heavy satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Nix only
5. pcs2-4mmm: heavy satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Kerberos only
6. pcs2-5mmm: heavy satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Hydra only
7. pcs2-6mmm light satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Nix only
8. pcs2-7mmm: light satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Hydra only
9. pcs2-n000.dat: summary of lifetimes for binary files in each archive 10. lifetime.c: summarizes lifetime and mass factor for binary file usage example: "lifetime pcs2-6110"
11. summary.c: generates basic summary of timesteps in a binary file usage example: "summary pcs1-0013d"
12. extrxyz.c: extracts (x,y,z) for N satellites and outputs (x,y,z) usage example: "extr6d pcs1-6110 6" will output (x,y,z) for SNKH 3. Additional related data collected that was not included in the current data package: There are other binary output files not included in this archive. 4. Are there multiple versions of the dataset? no
Micrometer-scale maps of authigenic microstructures in submarine basaltic tuff from a 1979 Surtsey volcano, Iceland, drill core acquired 15 years after eruptions terminated describe the initial alteration of oceanic basalt in a low temperature hydrothermal system. An integrative investigative approach uses synchrotron source X-ray microdiffraction (µXRD), microfluoresence (µXRF), micro-computed tomography (µCT), and scanning transmission electron microscopy (S/TEM) coupled with Raman spectroscopy to create finely resolved spatial frameworks that record a continuum of alteration in glass and olivine. Micro-analytical maps of vesicular and fractured lapilli in specimens from 157.1, 137.9, and 102.6 m depth, and borehole temperatures of 83, 93.9 and 141.3 °C measured in 1980, respectively, describe the production of nanocrystalline clay mineral, zeolites, and Al-tobermorite in diverse microenvironments. Irregular alteration fronts at 157.1 m depth resemble microchannels associated with biological activity in older basalts. By contrast, linear microstructures with little resemblance to previously described alteration features have nanocrystalline clay mineral (nontronite) and zeolite (amicite) texture. The crystallographic preferred orientation rotates around an axis parallel to the linear feature. Raman spectra indicating degraded and poorly-ordered carbonaceous matter of possible biological origin are associated with nanocrystalline clay mineral in a crystallographically-oriented linear microstructure in altered olivine at 102.6 m and with sub-circular nanoscale cavities in altered glass at 137.9 m depth. Although evidence for biotic processes is inconclusive, the integrated analyses describe the complex organization of previously unrecognized mineral texture in very young basalt. They provide a foundational mineralogical reference for longitudinal, time-lapse characterizations of palagonitized basalt in oceanic environments.
The data set includes individual images of mouse cochleae, both scanning electron micrographs and fluorescent micrographs, used to generate aggregated data described in Pecha PP, Almishaal AA, Mathur PD, et al. Role of Free Radical Formation in Murine Cytomegalovirus–Induced Hearing Loss. Otolaryngology–Head and Neck Surgery. 2020;162(5):709-717. doi:10.1177/0194599820901485 and Objectives
The goal of the study was to determine whether reactive oxygen species (ROS) mediates cytomegalovirus (CMV)–induced labyrinthitis.
Study Design
Murine model of CMV infection.
Subjects and Methods
Nrf2 knockout mice were inoculated with murine CMV. Auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs) were then performed on these and uninfected controls. BALB/c mice were inoculated with murine CMV to determine whether a marker for ROS production, dihydroethidium (DHE), is expressed 7 days after inoculation. Finally, 2 antioxidants—D-methionine and ACE-Mg (vitamins A, C, and E with magnesium)—were administered 1 hour before and after infection in inoculated mice for 14 days. Temporal bones were harvested at postnatal day 10 for DHE detection. ABR and DPOAE testing was done at postnatal day 30. Scanning electron microscopy was also performed at postnatal day 30 to evaluate outer hair cell integrity.
Results
Nrf2-infected mice had worse hearing than uninfected mice (P < .001). A statistically significant increase in DHE fluorescence was detected in BALB/c-infected mice as compared with uninfected mice 7 days after inoculation. D-methionine- and ACE-Mg-treated mice demonstrated an attenuation of the DHE fluorescence and a significant improvement in ABR and DPOAE thresholds when compared with untreated infected controls (P < .0001). Scanning electron microscopy demonstrated less outer hair cell loss in the treated versus untreated infected controls.
Conclusion
These results demonstrate for the first time that excessive ROS mediates CMV-induced hearing loss in a mouse model.
Light-scattering spectroscopy (LSS) is an established optical approach for nondestructive characterization of biological tissues. Here, we investigated the capabilities of LSS and convolutional neural networks (CNNs) to quantitatively characterize the composition and arrangement of cardiac tissues. We assembled tissue constructs from 200 μm thick sections of fixed myocardium and aortic wall. Thickness of the tissue constructs was similar to the thickness of atrial free wall. In the assembled constructs, the aortic sections represented fibrotic tissue and the depth, volume fraction, and arrangement of these fibrotic insets were varied. We gathered spectra with wavelengths from 500-1100 nm from the constructs at multiple locations relative to a light source. We used single and combinations of two spectra for training of CNNs. With independently measured spectra, we assessed the accuracy of the trained CNNs for classification of tissue constructs from single spectra and combined spectra. In general, classification accuracy with single spectra was smaller than with combined spectra. Combined spectra including spectra from fibers distal from the illumination fiber typically yielded a higher accuracy than proximal single collection fibers. Maximal classification accuracy of depth detection, volume fraction and permutated arrangements was (mean±stddev) 88.97±2.49%, 76.33±1.51% and 84.25±1.88%, respectively. Our studies demonstrate the reliability of quantitative characterization of tissue composition and arrangements using a combination of LSS and CNNs. Potential clinical applications of the developed approach include intraoperative quantification and mapping of atrial fibrosis as well as assessment of ablation lesions.
Subglacial water pressures influence groundwater conditions in proximal alpine valley rock slopes, varying with glacier advance and retreat in parallel with changing ice thickness. Fluctuating groundwater pressures in turn increase or reduce effective joint normal stresses, affecting the yield strength of discontinuities. Here we extend simplified assumptions of glacial debuttressing to investigate how glacier loading cycles together with changing groundwater pressures generate rock slope damage and prepare future slope instabilities. Using hydromechanical coupled numerical models closely based on the Aletsch Glacier valley in Switzerland, we simulate Late Pleistocene and Holocene glacier loading cycles including long-term and annual groundwater fluctuations. Measurements of transient subglacial water pressures from ice boreholes in the Aletsch Glacier ablation area, as well as continuous monitoring of bedrock deformation from permanent GNSS stations helps verify our model assumptions. While purely mechanical glacier loading cycles create only limited rock slope damage in our models, introducing a fluctuating groundwater table generates substantial new fracturing. Superposed annual groundwater cycles increase predicted damage. The cumulative effects are capable of destabilizing the eastern valley flank of our model in toppling-mode failure, similar to field observations of active landslide geometry and kinematics. We find that hydromechanical fatigue is most effective acting in combination with long-term loading and unloading of the slope during glacial cycles. Our results demonstrate that hydromechanical stresses associated with glacial cycles are capable of generating substantial rock slope damage and represent a key preparatory factor for paraglacial slope instabilities.
Future projections suggest an increase in drought globally with climate change. Current vegetation models typically regulate the plant photosynthetic response to soil moisture stress through an empirical function, rather than a mechanistic response where plant water potentials respond to changes in soil water. This representation of soil moisture stress may introduce significant uncertainty into projections for the terrestrial carbon cycle. We examined the use of the soil moisture limitation function in historical and future emissions scenarios in nine Earth system models. We found that soil moisture-limited productivity across models represented a large and uncertain component of the simulated carbon cycle, comparable to 3-286% of current global productivity. Approximately 40-80% of the intermodel variability was due to the functional form of the limitation equation alone. Our results highlight the importance of implementing mechanistic water limitation schemes in models and illuminate several avenues for improving projections of the land carbon sink.
: Forests play a major role in the global carbon cycle. Previous studies on the capacity of forests to sequester atmospheric CO2 have mostly focused on carbon uptake, but the roles of carbon turnover time and its spatiotemporal changes remain poorly understood. Here, we used long-term inventory data (1955-2018) from 695 mature forest plots to quantify temporal trends in living vegetation carbon turnover time across tropical, temperate, and cold climate zones, and compared plot data to eight Earth system models (ESMs). Long-term plots consistently showed decreases in living vegetation carbon turnover time, likely driven by increased tree mortality across all major climate zones. Changes in living vegetation carbon turnover time were negatively correlated with CO2 enrichment in both forest plot data and ESM simulations. However, plot-based correlations between living vegetation carbon turnover time and climate drivers such as precipitation and temperature diverged from those of ESM simulations. Our analyses suggest that forest carbon sinks are likely to be constrained by a decrease in living vegetation carbon turnover time, and accurate projections of forest carbon sink dynamics will require an improved representation of tree mortality processes and their sensitivity to climate in ESMs.
Background: The objective of this study was to evaluate the effect of utilising larger lens cubes on phacoemulsification efficiency and chatter using 3 tips of different sizes and 2 ultrasound (US) approaches.
Methods: This was an in vitro laboratory study conducted at the John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, UT, USA. Porcine lens nuclei were formalin-soaked for 2 hours, then divided into either 2.0 mm or 3.0 mm cubes. 30 degree bent 19 G, 20 G, and 21 G tips were used with a continuous torsional US system; and straight 19 G, 20 G, and 21 G tips were used with a micropulse longitudinal US system. Efficiency and chatter were determined.
Results: Mean phacoemulsification removal time was higher with the 3.0 mm lens cube for all US variations and tip sizes. There were statistically significant differences between the 19 G and 21 G tips with micropulse longitudinal US using the 2.0 mm lens cube and the 3.0 mm lens cube, as well as with continuous transversal US using the 2.0 mm lens cube and the 3.0 mm lens cube. There was no significant difference between 19 G and 20 G tips with either lens cube size in either US approach. However, using both US approaches, trends were identical for both lens cube sizes in which the 19 G tips performed better than the 20 G and 21 G tips.
Conclusion: Regardless of lens size, the 19 G needle was the most efficient, with the fewest outliers and smallest standard deviations.
This project was a NSF-funded collaborative research project entitled: Collaborative Research: Deciphering Eolian Paleoenvironmental and Hydrodynamic records: Lower Jurassic Navajo Sandstone, Colorado Plateau, USA This was a multifaceted interdisciplinary study of the Lower Jurassic Navajo Sandstone (Ss)--a unique and distinctive unit in all of geologic history. This unit represents the largest known ancient desert (erg), and is typically classified as a record of a hyperarid environment. Furthermore, the Navajo Ss was deposited at a time when mammals were undergoing their first major diversification, and dinosaurs began to dominate the landscape in number and diversity. Our goal was to examine sedimentary features of the erg margin that recorded the active paleohydrology of the desert regime, and examine abundant trace- and body-fossil material to more fully document the structure and evolution of the biota in a variably arid landscape through Navajo Ss deposition. Field studies involved sedimentology and paleoecology. Laboratory studies involved isotope geochemistry of carbonate deposits, as well as thin section petrography.
The widely documented phenomenon of nighttime stomatal conductance (gsn) could lead to substantial water loss with no carbon gain, and thus it remains unclear whether nighttime stomatal conductance confers a functional advantage. Given that studies of gsn have focused on controlled environments or small numbers of species in natural environments, a broad phylogenetic and biogeographic context could provide insights into potential adaptive benefits of gsn. • We measured gsn on a diverse suite of species (n = 73) across various functional groups and climates-of-origin in a common garden to study the phylogenetic and biogeographic/climatic controls on gsn and further assessed the degree to which gsn co-varied with leaf functional traits and daytime gas exchange rates. • Closely related species were more similar in gsn than expected by chance. Herbaceous species had higher gsn than woody species. Species that typically grow in climates with lower mean annual precipitation – where the fitness cost of water loss should be the highest – generally had higher gsn. • Our results reveal the highest gsn rates in species from environments where neighboring plants compete most strongly for water, suggesting a possible role for the competitive advantage of gsn.
The dynamic properties of freestanding rock landforms are a function of fundamental material and mechanical parameters, facilitating non-invasive vibration-based structural assessment. Characterization of resonant frequencies, mode shapes, and damping ratios, however, can be challenging at culturally-sensitive geologic features, such as rock arches, where physical access is limited. Using sparse ambient vibration measurements, we describe three resonant modes between 1 and 40 Hz for 17 natural arches in Utah spanning a range of lengths from 3 – 88 m. Modal polarization data are evaluated to combine field observations with 3-D numerical models. We find outcrop-scale elastic moduli vary from 0.8 to 8.0 GPa, correlated with diagenetic processes, and identify low damping at all sites. Dense-array cross-correlation results from an additional arch validate predictions of simple bending modes and fixed boundary conditions. Our results establish use of sparse ambient resonance measurements for structural assessment and monitoring of arches and similar freestanding geologic features.
The Andes Cordillera, which runs the length of South America and rises up to 5,000 m MSL within 200 km of the Pacific coast, dramatically influences the distribution of winter precipitation and snowpack over Chile and Argentina. The study of orographic precipitation processes, particularly along the western slopes of the Andes, is important to improve forecasts of severe flooding and snowpack in a region that depends on snowmelt for water resources. While orographic effects have been investigated on synoptic scales in the Andes, the lack of operational radar coverage and high-elevation, long-term precipitation records have, before the present study, precluded an in-depth investigation into the mesoscale and microphysical processes that affect the distribution of precipitation in the region.
This dataset was collected during the Chilean Orographic and Mesoscale Precipitation Study (ChOMPS), which, from May-October 2016, investigated the evolution of precipitation amounts, dropsize distribution, and the vertical profile of radar echoes along an east-west transect that stretched from the Pacific coast to the windward slope of the Andes. The transect, at ~36°S, was made up of a coastal site upstream of the coastal mountain range (Concepción), a central valley site (Chillán), and a mountain site (Las Trancas). Instrumentation along the transect included three vertically pointing Micro-Rain-Radars, two Parsivel Disdrometers, and several meteorological stations.
The dataset documents the evolution of Doppler velocity and reflectivity profiles with inland extent during early, middle, and late storm sectors. Additionally, the transect provides a season-long record of the inland evolution of melting layer height as well as the prevalence and structure of shallow non-brightband rain and the characteristics of its inland penetration to the central valley. This dataset, the first of its kind in the Chilean Andes, provides unique insight into mesoscale and orographic precipitation processes that also have applicability to the west coast of the United States and other mountainous regions.
Background. Common cold viruses create significant health and financial burdens, and understanding key loci of transmission would help focus control strategies. This study (1) examines factors that influence when individuals transition from a negative to positive test (acquisition) or a positive to negative test (loss) of rhinovirus (HRV) and other respiratory tract viruses in 26 households followed weekly for one year, (2) investigates evidence for intrahousehold and interhousehold transmission and the characteristics of individuals implicated in transmission, and (3) builds data-based simulation models to identify factors that most strongly affect patterns of prevalence. Methods. We detected HRV, coronavirus, paramyxovirus, influenza and bocavirus with the FilmArray polymerase chain reaction (PCR) platform (BioFire Diagnostics, LLC). We used logistic regression to find covariates affecting acquisition or loss of HRV including demographic characteristics of individuals, their household, their current infection status, and prevalence within their household and across the population. We apply generalized linear mixed models to test robustness of results. Results. Acquisition of HRV was less probable in older individuals and those infected with a coronavirus, and higher with a higher proportion of other household members infected. Loss of HRV is reduced with a higher proportion of other household members infected. Within households, only children and symptomatic individuals show evidence for transmission, while between households only a higher number of infected older children (ages 5-19) increases the probability of acquisition. Coronaviruses, paramyxoviruses and bocavirus also show evidence of intrahousehold transmission. Simulations show that age-dependent susceptibility and transmission have the largest effects on mean HRV prevalence. Conclusions. Children are most likely to acquire and most likely to transmit HRV both within and between households, with infectiousness concentrated in symptomatic children. Simulations predict that the spread of HRV and other respiratory tract viruses can be reduced but not eliminated by practices within the home.
Objective: In 2018, the Network of the National Libraries of Medicine (NNLM) launched a national sponsorship program to support U.S. public library staff in completing the Medical Library Association’s (MLA) Consumer Health Information Specialization (CHIS). The primary objective of this research project was to determine if completion of the sponsored specialization was successful in improving public library staff ability to provide consumer health information and whether it resulted in new services, programming, or outreach activities at public libraries. Secondary objectives of this research were to determine motivation for and benefits of the specialization and to determine the impact on sponsorship on obtaining and continuing the specialization.
Methods: To evaluate the sponsorship program, we developed and administered a 16-question online survey via REDCap in August 2019 to 224 public library staff that were sponsored during the first year of the program. We measured confidence and competence in providing consumer health information using questions aligned with the eight Core Competencies for Providing Consumer Health Information Services [1]. Additionally, the survey included questions about new consumer health information activities at public libraries, public library staff motivation to obtain the specialization, and whether it led to immediate career gains. To determine the overall value of the NNLM sponsorship, we measured whether funding made it more likely for participants to complete or continue the specialization.
Results: Overall, 136 participants (61%) responded to the survey. Our findings indicated that the program was a success: over 80% of participants reported an increase in core consumer health competencies, with a statistically significant improvement in mean competency scores after completing the specialization. Ninety percent of participants have continued their engagement with NNLM, and over half offered new health information programs and services at their public library. All respondents indicated that completing the specialization met their expectations, but few reported immediate career gains. While over half of participants planned to renew the specialization or obtain the more advanced, Level II specialization, 72% indicated they would not continue without the NNLM sponsorship.
Conclusion: Findings indicate that NNLM sponsorship of the CHIS specialization was successful in increasing the ability of public library staff to provide health information to their community. and This dataset represents the de-identified raw results of a 16-question, online survey (via REDCap) collected in August 2019 to 224 public library staff who were sponsored for a Consumer Health Information Specialization (CHIS). The purpose of the study was to determine whether the sponsorship program had an impact on public library staff to provide consumer health information.
Using a suite of numerical calculations, we consider the long-term evolution of
circumbinary debris from the Pluto--Charon giant impact. Initially, these solids
have large eccentricity and pericenters near Charon's orbit. On time scales of
100--1000 yr, dynamical interactions with Pluto and Charon lead to the ejection
of most solids from the system. As the dynamics moves particles away from the
barycenter, collisional damping reduces the orbital eccentricity of many particles.
These solids populate a circumbinary disk in the Pluto-Charon orbital plane; a large
fraction of this material lies within a `satellite zone' that encompasses the orbits
of Styx, Nix, Kerberos, and Hydra. Compared to the narrow rings generated from the
debris of a collision between a trans-Neptunian object (TNO) and Charon,
disks produced after the giant impact are much more extended and may be a less promising option for producing small circumbinary satellites.