Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.
This dataset accompanies the research article entitled, "Vibration of Natural Rock Arches and Towers Excited by Helicopter-Sourced Infrasound," where we investigate the vibration response of seven landforms to helicopter-sourced infrasound during controlled flight. Included are time-series vibration data of the landforms and nearby ground during and before helicopter flight, time-series infrasound data, 3D photogrammetry models of the studied landforms, and GPS data from the helicopter.
This collection includes radial component displacement seismograms in the time window including the SKS, SKKS and SPdKS seismic arrivals. These data all interact with ultra-low velocity zone (ULVZ) structures at the core-mantle boundary beneath East Asia. Data used in the study of Festin et al., 2024 (TSR) is included in this collection.
The data from the Digital Library Outreach and Instruction survey is intended to discover how digital library practitioners at various types of cultural institutions promote their unique resources, beyond simply placing content in an online repository for users to discover. Types of outreach investigated include social media promotion, integration of digital collections into teaching and instruction activities, and partnerships with external campus units or community organizations.
In the element database, major elements are reported in weight percent oxide (wt%). Trace element concentrations are reported in parts per million (ppm). Available lithologic information (“lithology” column) and the type of igneous sample (intrusive or extrusive in the “Sample-Type” column) were included. The name of the area or of the corresponding igneous body were included when available (“Location/Body-Name” column). The location of the samples is reported in decimal degrees (WGS84), however, uncertainties explained below must be considered. Coordinates were obtained from three different ways of presenting the information about the location. The three scenarios are distinguished as “GPS”, “Figure-Point”, and “Figure-Polygon” in the “Location-Type” column. Samples with a location in a coordinate system were transformed to decimal degrees (WGS84) and classified as “GPS”. Samples individually identified in a georeferenced geologic map were approximately located after georeferencing the map in Google Earth or ArcGis (“Figure-Point”). Samples identified with a polygon in a georeferenced map (through age, body name or unidentified sample locations), but without more detailed information were approximately located in the middle of the corresponding polygon after georeferencing the map in Google Earth or ArcGis (“Figure-Polygon”). Precise “GPS” locations were obtained for 358 analyses, and approximate locations were obtained for 428 analyses. The age information was organized using three categories: “Age-Approximation”, “Age-number”, and “Age-Error”. “Age-approximation” corresponds to the age information from original paper or from an additional reference detailed in the “Reference-Age” column. “Age-number” corresponds to the age reported in the original paper or previous compilation, or to the average age calculated from a given age range. “Age-Error” corresponds to the error presented in the original paper or previous compilation, or to half of the age range. Information about the methods, analyzed material and laboratory name was included when available. Lastly, the original data sources are available in the “Reference” column. References from previous compilations incorporated in this database are specified as “Compilation-Reference”. Additional references used for constraining the age are detailed in “Reference-Age” column.
Data that were incorrectly reported (e.g., reporting average compositions instead of sample composition) or with anomalous trace element concentrations were filtered-out from the element database. Analyses from weathered or altered samples producing high total volatile content (LOI> 5 wt%) were removed. Samples with no available information to approximately locate them or to constrain their age were eliminated. Despite this screening process, the database suffers from uncertainties related to approximated ages and locations and variable information regarding the lithology, and availability of trace elements The inhomogeneity in this database is explicit and uncertainties related to the age and location should be carefully considered in any interpretation. The final compilation contains 787 geochemical analyses (major, minor and trace elements) and includes data from 36 studies.
Isotopic data in this database includes 863 samples from 34 papers and three previously published compilations. For each sample, this database provides location, age, and reference information presented in the first columns. Locations are recorded in latitude and longitude (WGS84). The information about the location source uses the same criteria used for the elemental geochemical database (“GPS”, “Figure-Polygon” and “Figure-Point”). Age is provided according to the original source and includes two general scenarios: an age with uncertainty at 2σ level and a general estimation for the age with no associated error. Sm-Nd and Rb-Sr data are based on whole rock analysis. Lu-Hf data are based on zircon analysis. Sm-Nd data includes Sm and Nd in ppm, 147Nd/144Nd and 143Nd/144Nd in ratios, Nd uncertainties at 2σ level, and Nd values in the epsilon notation as presented in the data source. Rb-Sr data include Rb and Sr in ppm; 87Rb/86Sr, 87Sr/86Sr, and initial 87Sr/86Sr in ratios, and Sr uncertainties at 2σ level. Lu-Hf data includes 176Yb/177Hf, 176Lu/177Hf, and 176Hf/177Hf rations and their uncertainties at 2σ level, the initial 176/177Hf ratio, Hf values in the epsilon notation and Hf uncertainties at 1σ and 2σ level, all as presented in the data source. Uncertainties related to the data location and heterogenous data distribution should be considered. Samples for the two batholiths in Mongolia are concentrated in central Mongolia and include Sm-Nd and Lu-Hf data. In the Erguna and Xing’an magmatic provinces, available samples provide mainly Lu-Hf data which are relatively better distributed than in the other regions.
This dataset provides access to data from personnel records of miner employment from 1900–1919. Records from the Utah Copper Company are handwritten and contain the following employee information: name, date employed, address, dependents, age, weight, height, eyes, hair, gender, and nationality. Data has been transcribed and released as a .tsv (Tab Separated Values) file. Technical metadata has been redacted.
This dataset contains room occupancy during the study period at University of Utah hospital. Admission, Discharge, and Transfer (ADT) data is captured in participating hospitals to characterize room occupancy and non-occupancy in wards. These data are pulled from multiple sources collected during the study by study staff as well as harvested EHR data. Data were adjudicated and compiled into one comprehensive file. Data manipulation included redaction of dates, replaced with study days 1-n, as well as transformation from long format to wide for ease of use.
The objective of using the wireless sensors was to improve understanding of the heterogeneity of healthcare worker (HCW) contact with patients and the physical environment in patients’ rooms. The framework and design were based on contact networks with a) nodes defined by HCW’s, rooms, and items in the room and b) edges defined by HCW’s in the room, near the bed, and touching items. Nodes had characteristics of HCW role and room number. Edges had characteristics of day, start time, and duration. Thus, patterns and heterogeneity could be understood within contexts of time, space, roles, and patient characteristics. At the University of Utah Hospital Cardiovascular ICU (CVICU), a 20-bed unit, we collected data for 54 days. HCW contact with patients was measured using wireless sensors to capture time spent in patient rooms as well as time spent near the patient bed. HCW contact with the physical environment was measured using wireless sensors on the following items in patient rooms: door, sink, toilet, over-bed table, keyboard, vital signs monitor touchscreen, and cart. HCW’s clipped a sensor to their clothing or lanyard. This dataset contains cleaned sensor pings of RFD reads between healthcare worker worn sensors and environmental sensors placed in facility using methods described in the "Data Cleaning Steps" section.