We determined whether a large, multi-analyte panel of circulating biomarkers can improve detection of early-stage pancreatic ductal adenocarcinoma (PDAC). We defined a biologically relevant subspace of blood analytes based on previous identification in premalignant lesions or early-stage PDAC and evaluated each in pilot studies. The 31 analytes that met minimum diagnostic accuracy were measured in serum of 837 subjects (461 healthy, 194 benign pancreatic disease, 182 early stage PDAC). We used machine learning to develop classification algorithms using the relationship between subjects based on their changes across the predictors. Model performance was subsequently evaluated in an independent validation data set from 186 additional subjects.
This dataset encompasses the results of a series of controlled experiments conducted at the University of Utah's Industrial Hygiene Research Laboratory between November 2021 and November 2022. It includes data from tests assessing aerosol containment and surface contamination using the U-COVER device. The dataset details the effectiveness of different device designs (D1A, D1B, D2) in containing salt aerosols under various conditions, including with and without exhaust ventilation. Measurements were conducted using GRIMM Model 1.109 Portable Aerosol Spectrometers and analyzed for particle size distributions and concentrations. The findings provide insights into the protective capabilities of the U-COVER device in medical settings, with implications for healthcare worker safety."
This dataset covers all of the marbriers (stonecutters) listed in the commercial almanacs for the city of Paris from 1798 to 1907. The author used the almanacs available digitally on the Bibliothèque nationale de France's digital library, Gallica (gallica.bnf.fr). The dataset was initially compiled to study the development of the funerary monuments industry in Paris, although the dataset aggregates all stonemasons' enterprises and ateliers regardless of their field of specialization. Binary variables are included in the dataset, based on text descriptions in the almanacs, to indicate named areas of specialization.
Historically, the compilation of the annual commercial almanacs was a project undertaken by two different publishers (Bottin and Firmin Didot), who eventually merged in 1857. Every year, in addition to the information that had already been collected, corrections and additions were solicited from the general public. According to the notice included at the beginning of the 1838 issue, listing in the almanac was (and always had been) free. If one wanted details in addition to a general category of work to be included in a record, individuals needed to contact the editor directly (there is no mention of what this might have cost). See: Sébastien Bottin, Almanach du commerce de Paris, des départemens de la France, et des principals villes du monde (Paris, 1838); and Firmin Didot et Bottin Réunis, Annuaire et almanac du commerce, de l’industrie, de la magistrature et de l’administration (Paris: 1857).
The dataset was collected in the process of carrying out a research on the effects of photochemical aging and interactions with secondary organic aerosols on cellular toxicity of combustion particles between the year 2021 to 2022
This dataset accounts for all jobs undertaken by the Société Le Roy Bouillon, a funerary monuments company in Paris, from 1890 to 1902. The first sheet, “Activity Data” accounts for each job and the fee charged to the client for that job. It also categories each job as either a new cemetery construction, maintenance to existing cemetery structures, or other jobs unrelated to cemetery construction. The second sheet, “Outside Paris,” summarizes the annual activity, recording the number of projects undertaken within Paris versus outside of the city, new constructions versus maintenance work, and revenue coming in from each type of job. The original records are currently housed in a private collection in Paris and were manually transcribed by the author.
This dataset summarizes burial counts according to burial type (free, temporary, or perpetual) for the cemeteries of Père-Lachaise, Montmartre, and Montparnasse in Paris. The data covers the period of 1804 to 1840 and was derived from the digitized daily records of burial for the city of Paris, which are currently held in the Archives de Paris. See Registres journaliers d'inhumation https://archives.paris.fr/r/216/cimetieres). These data are organized by the number of each burial type recorded per page of the digitized records.
The data was obtained from the FDTD simulations. For one of the FDTD simulations, the conductivity data for British Columbia was used in order to obtain the simulated data. The data obtained from simulations are post-processed using MATLAB for plotting the figures in the paper.
The COVID-19 pandemic disrupted scientific research, teaching, and learning in higher education and forced many institutions to explore new modalities in response to the abrupt shift to remote learning. Accordingly, many colleges and universities struggled to provide the training, technology, and best practices to support faculty and students, especially those at historically disadvantaged and underrepresented institutions. In this study we investigate different remote learning modalities to improve and enhance research education training for faculty and students. We specifically focus on Responsible and Ethical Conduct of Research (RECR) and Research Mentoring content to help address the newly established requirements of the National Science Foundation for investigators. To address this need we conducted a workshop to determine the effectiveness of three common research education modalities: Live Lecture, Podcast, and Reading. The Live Lecture sessions provided the most evidence of learning based on the comparison between pre- and post-test results, whereas the Podcast format was well received but produced a slight (and non-significant) decline in scores between the pre- and post-tests. The Reading format showed no significant improvement in learning. The results of our workshop illuminate the effectiveness and obstacles associated with various remote learning modalities, enabling us to pinpoint areas that require additional refinement and effort, including the addition of interactive media in Reading materials.
The purpose of this derived dataset was to analyze menstrual cycle lengths in relation to lunar calendar. This datafile of start and end date of 3324 menstrual cycles of 581 women is part of a combined dataset of three cohorts of heterosexually active women who received instruction in the Creighton Model FertilityCare System (CrM) through centres across the United States and Canada. The CrM has standardised protocols for teaching women how to observe, record, and interpret daily vaginal discharge from bleeding and cervical fluid on a daily diary, called a CrM chart, and to use these standardised observations to identify the estimated time of ovulation and days when intercourse is likely to result in pregnancy. The cohorts included: "Creighton Model Effectiveness, Intentions, and Behaviours Assessment" (CEIBA) (2009–2013), a prospective cohort of women without known subfertility, aimed to evaluate and classify pregnancy rates and pregnancy intentions during use of the CrM; "Creighton Model MultiCenter Fecundability Study" (CMFS) (1990–1996), a retrospective cohort of presumably fertile and subfertile women using CrM, aimed to assess the relationship between vulvar mucus observations and the day and cycle-specific probabilities of conception; and "Time to Pregnancy in Normal Fertility" (TTP) (2003–2006), a parallel-randomised trial, which aimed to assess the impact of CrM use on time to pregnancy in couples of proven fertility trying to conceive. Each of the cohorts aimed to include heterosexually active couples with normal fecundity. Eligibility criteria were assessed by women's responses to the CrM general intake form and/or a screening questionnaire. Eligibility requirements in the original studies included women, age 18–40 years old (upper limit of 35 years for TTP), not pregnant at entry, having regular menstrual bleeding, and not breast feeding (CMFS and TTP), or if breast feeding, not doing so exclusively (CEIBA). Recent users of oral contraceptives had to have at least one menstrual bleed (CEIBA) or two menstrual bleeds (TTP) since stopping the oral contraceptives; however, for CMFS there was no restriction for time since discontinuing oral contraceptives. All studies also required normal menstrual patterns since last use of depo-medroxy-progesterone acetate or a hormonal intra-uterine device.
This data set contains 12-hour manual new snow and liquid precipitation equivalent (LPE) observations collected at the Alta-Collins (CLN) snow-study plot during the 2000–2023 cool seasons (October 1–April 30 with the year defined by the ending calendar year). CLN is located mid-mountain at Alta Ski Area in the Wasatch Range of northern Utah (approximately 111.63889W, 40.57607N) at an elevation of 2945 m.
This study investigates the internal facies architecture of a river-dominated delta deposit using outcrops of the Cretaceous Panther Tongue of the Star Point Sandstone in central Utah, U.S.A. A series of photorealistic virtual outcrop models (VOM) were created from ~13 linear-km of outcrop. These VOMs, alongside field observations, were used to identify and map facies and facies associations over the ~25 m-thick stratigraphic interval. A new workflow for querying VOMs as outcrop analogs for subsurface reservoir analogs was developed, using a database of measurements (Panther Tongue - outcrop analog - metric database) was constructed using 60 digital sections that were measured within the VOMs at 152 m (~500 ft) spacing. This database characterizes a total of 508 sandstone beds by their thickness, length, and dip, from which the average thickness (0.78 m), bed length (330 m), and bed dip (2˚ towards the south) were calculated. Thinning rates were also calculated in both depositional strike and depositional dip directions (1.37x10-2 and 1.01x10-2 respectively). The workflow established in this study is applicable to other sedimentary outcrops and environments, thus demonstrating that VOMs can be used as a basis for quantitative database development and reservoir modeling inputs.
The objective of using the wireless sensors was to improve understanding of the heterogeneity of healthcare worker (HCW) contact with patients and the physical environment in patients’ rooms. The framework and design were based on contact networks with a) nodes defined by HCW’s, rooms, and items in the room and b) edges defined by HCW’s in the room, near the bed, and touching items. Nodes had characteristics of HCW role and room number. Edges had characteristics of day, start time, and duration. Thus, patterns and heterogeneity could be understood within contexts of time, space, roles, and patient characteristics. At the University of Utah Hospital Cardiovascular ICU (CVICU), a 20-bed unit, we collected data for 54 days. HCW contact with patients was measured using wireless sensors to capture time spent in patient rooms as well as time spent near the patient bed. HCW contact with the physical environment was measured using wireless sensors on the following items in patient rooms: door, sink, toilet, over-bed table, keyboard, vital signs monitor touchscreen, and cart. HCW’s clipped a sensor to their clothing or lanyard.
Abstract from Paper (Lange et. al, 2022): Atypical atrial flutter is seen post-ablation in patients, and it can be challenging to map. These flutters are typically set up around areas of scar in the left atrium. MRI can reliably identify left atrial scar. We propose a personalized computational model using patient specific scar information, to generate a monodomain model. In the model conductivities are adjusted for different tissue regions and flutter was induced with a premature pacing protocol. The model was tested prospectively in patients undergoing atypical flutter ablation. The simulation-predicted flutters were visualized and presented to clinicians. Validation of the computational model was motivated by recording from electroanatomical mapping. These personalized models successfully predicted clinically observed atypical flutter circuits and at times even better than invasive maps leading to flutter termination at isthmus sites predicted by the model.
This dataset contains code used to generate and the results of 2D numerical modeling simulations of ambient resonance in damaged rock slopes. All simulations were performed using the Universal Distinct Element Code (UDEC) version 7.0. We simulated progressive damage for three different landslide types: slab toppling, flexural toppling, and planar sliding. For each scenario we simulated several stages of progressive rock slope damage. Subsequently, we recorded the resonance response of the rock slope at each stage by measuring x-direction velocity at one or more measuring points throughout the model.
This dataset contains GIS map data and monitoring datasets collected between 2018 and 2022 at the Courthouse Mesa rock slope instability near Moab, Utah. Map data consist of an orthophoto, a polyline shapefile delineating mapped surficial cracks, and a point shapefile showing the locations of crack width monitoring points (M1–M5) and a vibrating wire crackmeter. Monitoring data include four years of continuous crack aperture measurements from the crackmeter, periodic crack width measurements from M1–M5, and three sets of air temperature measurements recorded between 2018 and 2022. Air temperatures were measured at the surface and inside the crack at several depths throughout the monitoring period.
Localization of the components of the cardiac conduction system (CCS) is essential for many therapeutic procedures in cardiac surgery and interventional cardiology. While histological studies provided fundamental insights into CCS localization, this information is incomplete and difficult to translate to aid in intraprocedural localization. To advance our understanding of CCS localization, we set out to establish a framework for quantifying nodal region morphology. Using this framework, we quantitatively analyzed the sinoatrial node (SAN) and atrioventricular node (AVN) in ovine with menstrual age ranging from 4.4 to 58.3 months. In particular, we studied the SAN and AVN in relation to the epicardial and endocardial surfaces, respectively. Using anatomical landmarks, we excised the nodes and adjacent tissues, sectioned those at a thickness of 4 µm at 100 µm intervals, and applied Masson’s trichrome stain to the sections. These sections were then imaged, segmented to identify nodal tissue, and analyzed to quantify nodal depth and superficial tissue composition. The minimal SAN depth ranged between 20 and 926 µm. AVN minimal depth ranged between 59 and 1192 µm in the AVN extension region, 49 and 980 µm for the compact node, and 148 and 888 µm for the transition to His Bundle region. Using a logarithmic regression model, we found that minimal depth increased logarithmically with age for the AVN (R2=0.818, P=0.002). Also, the myocardial overlay of the AVN was heterogeneous within different regions and decreased with increasing age. Age associated alterations of SAN minimal depth were insignificant. Our study presents examples of characteristic tissue patterns superficial to the AVN and within the SAN. We suggest that the presented framework provides quantitative information for CCS localization. Our studies indicate that procedural methods and localization approaches in regions near the AVN should account for the age of patients in cardiac surgery and interventional cardiology.
We apply Bayesian inference to instrument calibration and experimental-data uncertainty analysis for the specific application of measuring radiative intensity with a narrow-angle radiometer. We develop a physics-based instrument model that describes temporally varying radiative intensity, the indirectly measured quantity of interest, as a function of scenario and model parameters. We identify a set of five uncertain parameters, find their probability distributions (the posterior or inverse problem) given the calibration data by applying Bayes’ Theorem, and employ a local linearization to marginalize the nuisance parameters resulting from errors-in-variables. We then apply the instrument model to a new scenario that is the intended use of the instrument, a 1.5 MW coal-fired furnace. Unlike standard error propagation, this Bayesian method infers values for the five uncertain parameters by sampling from the posterior distribution and then computing the intensity with quantifiable uncertainty at the point of a new, in-situ furnace measurement (the posterior predictive or forward problem). Given the instrument-model context of this analysis, the propagated uncertainty provides a significant proportion of the measurement error for each in-situ furnace measurement. With this approach, we produce uncertainties at each temporal measurement of the radiative intensity in the furnace, successfully identifying temporal variations that were otherwise indistinguishable from measurement uncertainty.
-------------------------- METHODOLOGICAL INFORMATION --------------------------
1. Description of methods used for collection/generation of data: The data were generated by computer simulations using the C++ code "Orchestra", a proprietary hybrid code that follows the dynamical evolution of solids and gas orbiting a central object. Algorithms in the code are described in the following papers (author names abbreviated to B for Bromley, K for Kenyon, and L for Jane X Luu along with a year for publication date, AJ = Astronomical Journal, ApJ = Astrophysical Journal, S=Supplement): KL1998, AJ 115:2136; KL1999, AJ 118:1101; KB2001,AJ 121:538; KB2002,AJ 123:1757; KB2004, AJ 127:513; BK2006, AJ 131:2737; KB2006, AJ 131:1837; KB2008, ApJS 179:451; KB2010, ApJS 188:242; BK2011, ApJ 731:101; KB2012, AJ 143:63; KB2014, AJ 147:8. Initial conditions for these simulations described in the published paper.
2. Methods for processing the data: Various C and fortran programs are used to analyze the data for the calculations. Several C programs needed to extract information from the computer generated binary output files are included with the dataset. The C programs include basic summaries of the structure of the data files and the usage to extract data from each binary file.
3. Instrument- or software-specific information needed to interpret the data: Appropriate software is included in directory.
4. Standards and calibration information, if appropriate: none
5. Environmental/experimental conditions: all calculations were run on the NASA discover cluster
6. Describe any quality-assurance procedures performed on the data: Aside from tests summarized in the papers described in item 1, test calculations are summarized in the Appendix of each paper and compared to an appropriate benchmark.
7. People involved with sample collection, processing, analysis and/or submission: Scott Kenyon and Ben Bromley and --------------------- DATA & FILE OVERVIEW ---------------------
Files summarized in items 1-8 are binary output files from n-body simulations as described in Kenyon & Bromley, "A Pluto-Charon Sonata: Dynamical Limits on fate Masses of the Small Satellites" (2019, Astronomical Journal). Files described in item 9 are ascii txt. The C programs in items 10, 11, and 12 provide different ways to access the binary output. Each C program describes the architecture of the binary files.
1. pcs2-0mmm-nnn[a-z] files: heavy satellites, mmm = 100 x mass factor for all satellites, nnn = number of Symplectic steps per PC orbit, a-z = version
2. pcs2-1mmm-nnn[a-z] files: light satellites, mmm = 100 x mass factor for all satellites, nnn = number of Symplectic steps per PC orbit, a-z = version
3. pcs2-2mmm-nnn[a-z] files: light satellites with 2x nominal mass of Styx & Kerberos, mmm = 100 x mass factor for all satellites, nnn = number of Symplectic steps per PC orbit, a-z = version
4. pcs2-3mmm: heavy satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Nix only
5. pcs2-4mmm: heavy satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Kerberos only
6. pcs2-5mmm: heavy satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Hydra only
7. pcs2-6mmm light satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Nix only
8. pcs2-7mmm: light satellites, 40 Symplectic steps per PC orbit, mmm = 100 x mass factor for Hydra only
9. pcs2-n000.dat: summary of lifetimes for binary files in each archive 10. lifetime.c: summarizes lifetime and mass factor for binary file usage example: "lifetime pcs2-6110"
11. summary.c: generates basic summary of timesteps in a binary file usage example: "summary pcs1-0013d"
12. extrxyz.c: extracts (x,y,z) for N satellites and outputs (x,y,z) usage example: "extr6d pcs1-6110 6" will output (x,y,z) for SNKH 3. Additional related data collected that was not included in the current data package: There are other binary output files not included in this archive. 4. Are there multiple versions of the dataset? no
Micrometer-scale maps of authigenic microstructures in submarine basaltic tuff from a 1979 Surtsey volcano, Iceland, drill core acquired 15 years after eruptions terminated describe the initial alteration of oceanic basalt in a low temperature hydrothermal system. An integrative investigative approach uses synchrotron source X-ray microdiffraction (µXRD), microfluoresence (µXRF), micro-computed tomography (µCT), and scanning transmission electron microscopy (S/TEM) coupled with Raman spectroscopy to create finely resolved spatial frameworks that record a continuum of alteration in glass and olivine. Micro-analytical maps of vesicular and fractured lapilli in specimens from 157.1, 137.9, and 102.6 m depth, and borehole temperatures of 83, 93.9 and 141.3 °C measured in 1980, respectively, describe the production of nanocrystalline clay mineral, zeolites, and Al-tobermorite in diverse microenvironments. Irregular alteration fronts at 157.1 m depth resemble microchannels associated with biological activity in older basalts. By contrast, linear microstructures with little resemblance to previously described alteration features have nanocrystalline clay mineral (nontronite) and zeolite (amicite) texture. The crystallographic preferred orientation rotates around an axis parallel to the linear feature. Raman spectra indicating degraded and poorly-ordered carbonaceous matter of possible biological origin are associated with nanocrystalline clay mineral in a crystallographically-oriented linear microstructure in altered olivine at 102.6 m and with sub-circular nanoscale cavities in altered glass at 137.9 m depth. Although evidence for biotic processes is inconclusive, the integrated analyses describe the complex organization of previously unrecognized mineral texture in very young basalt. They provide a foundational mineralogical reference for longitudinal, time-lapse characterizations of palagonitized basalt in oceanic environments.
The data set includes individual images of mouse cochleae, both scanning electron micrographs and fluorescent micrographs, used to generate aggregated data described in Pecha PP, Almishaal AA, Mathur PD, et al. Role of Free Radical Formation in Murine Cytomegalovirus–Induced Hearing Loss. Otolaryngology–Head and Neck Surgery. 2020;162(5):709-717. doi:10.1177/0194599820901485 and Objectives
The goal of the study was to determine whether reactive oxygen species (ROS) mediates cytomegalovirus (CMV)–induced labyrinthitis.
Study Design
Murine model of CMV infection.
Subjects and Methods
Nrf2 knockout mice were inoculated with murine CMV. Auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs) were then performed on these and uninfected controls. BALB/c mice were inoculated with murine CMV to determine whether a marker for ROS production, dihydroethidium (DHE), is expressed 7 days after inoculation. Finally, 2 antioxidants—D-methionine and ACE-Mg (vitamins A, C, and E with magnesium)—were administered 1 hour before and after infection in inoculated mice for 14 days. Temporal bones were harvested at postnatal day 10 for DHE detection. ABR and DPOAE testing was done at postnatal day 30. Scanning electron microscopy was also performed at postnatal day 30 to evaluate outer hair cell integrity.
Results
Nrf2-infected mice had worse hearing than uninfected mice (P < .001). A statistically significant increase in DHE fluorescence was detected in BALB/c-infected mice as compared with uninfected mice 7 days after inoculation. D-methionine- and ACE-Mg-treated mice demonstrated an attenuation of the DHE fluorescence and a significant improvement in ABR and DPOAE thresholds when compared with untreated infected controls (P < .0001). Scanning electron microscopy demonstrated less outer hair cell loss in the treated versus untreated infected controls.
Conclusion
These results demonstrate for the first time that excessive ROS mediates CMV-induced hearing loss in a mouse model.
Light-scattering spectroscopy (LSS) is an established optical approach for nondestructive characterization of biological tissues. Here, we investigated the capabilities of LSS and convolutional neural networks (CNNs) to quantitatively characterize the composition and arrangement of cardiac tissues. We assembled tissue constructs from 200 μm thick sections of fixed myocardium and aortic wall. Thickness of the tissue constructs was similar to the thickness of atrial free wall. In the assembled constructs, the aortic sections represented fibrotic tissue and the depth, volume fraction, and arrangement of these fibrotic insets were varied. We gathered spectra with wavelengths from 500-1100 nm from the constructs at multiple locations relative to a light source. We used single and combinations of two spectra for training of CNNs. With independently measured spectra, we assessed the accuracy of the trained CNNs for classification of tissue constructs from single spectra and combined spectra. In general, classification accuracy with single spectra was smaller than with combined spectra. Combined spectra including spectra from fibers distal from the illumination fiber typically yielded a higher accuracy than proximal single collection fibers. Maximal classification accuracy of depth detection, volume fraction and permutated arrangements was (mean±stddev) 88.97±2.49%, 76.33±1.51% and 84.25±1.88%, respectively. Our studies demonstrate the reliability of quantitative characterization of tissue composition and arrangements using a combination of LSS and CNNs. Potential clinical applications of the developed approach include intraoperative quantification and mapping of atrial fibrosis as well as assessment of ablation lesions.
Subglacial water pressures influence groundwater conditions in proximal alpine valley rock slopes, varying with glacier advance and retreat in parallel with changing ice thickness. Fluctuating groundwater pressures in turn increase or reduce effective joint normal stresses, affecting the yield strength of discontinuities. Here we extend simplified assumptions of glacial debuttressing to investigate how glacier loading cycles together with changing groundwater pressures generate rock slope damage and prepare future slope instabilities. Using hydromechanical coupled numerical models closely based on the Aletsch Glacier valley in Switzerland, we simulate Late Pleistocene and Holocene glacier loading cycles including long-term and annual groundwater fluctuations. Measurements of transient subglacial water pressures from ice boreholes in the Aletsch Glacier ablation area, as well as continuous monitoring of bedrock deformation from permanent GNSS stations helps verify our model assumptions. While purely mechanical glacier loading cycles create only limited rock slope damage in our models, introducing a fluctuating groundwater table generates substantial new fracturing. Superposed annual groundwater cycles increase predicted damage. The cumulative effects are capable of destabilizing the eastern valley flank of our model in toppling-mode failure, similar to field observations of active landslide geometry and kinematics. We find that hydromechanical fatigue is most effective acting in combination with long-term loading and unloading of the slope during glacial cycles. Our results demonstrate that hydromechanical stresses associated with glacial cycles are capable of generating substantial rock slope damage and represent a key preparatory factor for paraglacial slope instabilities.
Future projections suggest an increase in drought globally with climate change. Current vegetation models typically regulate the plant photosynthetic response to soil moisture stress through an empirical function, rather than a mechanistic response where plant water potentials respond to changes in soil water. This representation of soil moisture stress may introduce significant uncertainty into projections for the terrestrial carbon cycle. We examined the use of the soil moisture limitation function in historical and future emissions scenarios in nine Earth system models. We found that soil moisture-limited productivity across models represented a large and uncertain component of the simulated carbon cycle, comparable to 3-286% of current global productivity. Approximately 40-80% of the intermodel variability was due to the functional form of the limitation equation alone. Our results highlight the importance of implementing mechanistic water limitation schemes in models and illuminate several avenues for improving projections of the land carbon sink.
: Forests play a major role in the global carbon cycle. Previous studies on the capacity of forests to sequester atmospheric CO2 have mostly focused on carbon uptake, but the roles of carbon turnover time and its spatiotemporal changes remain poorly understood. Here, we used long-term inventory data (1955-2018) from 695 mature forest plots to quantify temporal trends in living vegetation carbon turnover time across tropical, temperate, and cold climate zones, and compared plot data to eight Earth system models (ESMs). Long-term plots consistently showed decreases in living vegetation carbon turnover time, likely driven by increased tree mortality across all major climate zones. Changes in living vegetation carbon turnover time were negatively correlated with CO2 enrichment in both forest plot data and ESM simulations. However, plot-based correlations between living vegetation carbon turnover time and climate drivers such as precipitation and temperature diverged from those of ESM simulations. Our analyses suggest that forest carbon sinks are likely to be constrained by a decrease in living vegetation carbon turnover time, and accurate projections of forest carbon sink dynamics will require an improved representation of tree mortality processes and their sensitivity to climate in ESMs.
Background: The objective of this study was to evaluate the effect of utilising larger lens cubes on phacoemulsification efficiency and chatter using 3 tips of different sizes and 2 ultrasound (US) approaches.
Methods: This was an in vitro laboratory study conducted at the John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, UT, USA. Porcine lens nuclei were formalin-soaked for 2 hours, then divided into either 2.0 mm or 3.0 mm cubes. 30 degree bent 19 G, 20 G, and 21 G tips were used with a continuous torsional US system; and straight 19 G, 20 G, and 21 G tips were used with a micropulse longitudinal US system. Efficiency and chatter were determined.
Results: Mean phacoemulsification removal time was higher with the 3.0 mm lens cube for all US variations and tip sizes. There were statistically significant differences between the 19 G and 21 G tips with micropulse longitudinal US using the 2.0 mm lens cube and the 3.0 mm lens cube, as well as with continuous transversal US using the 2.0 mm lens cube and the 3.0 mm lens cube. There was no significant difference between 19 G and 20 G tips with either lens cube size in either US approach. However, using both US approaches, trends were identical for both lens cube sizes in which the 19 G tips performed better than the 20 G and 21 G tips.
Conclusion: Regardless of lens size, the 19 G needle was the most efficient, with the fewest outliers and smallest standard deviations.
This project was a NSF-funded collaborative research project entitled: Collaborative Research: Deciphering Eolian Paleoenvironmental and Hydrodynamic records: Lower Jurassic Navajo Sandstone, Colorado Plateau, USA This was a multifaceted interdisciplinary study of the Lower Jurassic Navajo Sandstone (Ss)--a unique and distinctive unit in all of geologic history. This unit represents the largest known ancient desert (erg), and is typically classified as a record of a hyperarid environment. Furthermore, the Navajo Ss was deposited at a time when mammals were undergoing their first major diversification, and dinosaurs began to dominate the landscape in number and diversity. Our goal was to examine sedimentary features of the erg margin that recorded the active paleohydrology of the desert regime, and examine abundant trace- and body-fossil material to more fully document the structure and evolution of the biota in a variably arid landscape through Navajo Ss deposition. Field studies involved sedimentology and paleoecology. Laboratory studies involved isotope geochemistry of carbonate deposits, as well as thin section petrography.
The widely documented phenomenon of nighttime stomatal conductance (gsn) could lead to substantial water loss with no carbon gain, and thus it remains unclear whether nighttime stomatal conductance confers a functional advantage. Given that studies of gsn have focused on controlled environments or small numbers of species in natural environments, a broad phylogenetic and biogeographic context could provide insights into potential adaptive benefits of gsn. • We measured gsn on a diverse suite of species (n = 73) across various functional groups and climates-of-origin in a common garden to study the phylogenetic and biogeographic/climatic controls on gsn and further assessed the degree to which gsn co-varied with leaf functional traits and daytime gas exchange rates. • Closely related species were more similar in gsn than expected by chance. Herbaceous species had higher gsn than woody species. Species that typically grow in climates with lower mean annual precipitation – where the fitness cost of water loss should be the highest – generally had higher gsn. • Our results reveal the highest gsn rates in species from environments where neighboring plants compete most strongly for water, suggesting a possible role for the competitive advantage of gsn.
The dynamic properties of freestanding rock landforms are a function of fundamental material and mechanical parameters, facilitating non-invasive vibration-based structural assessment. Characterization of resonant frequencies, mode shapes, and damping ratios, however, can be challenging at culturally-sensitive geologic features, such as rock arches, where physical access is limited. Using sparse ambient vibration measurements, we describe three resonant modes between 1 and 40 Hz for 17 natural arches in Utah spanning a range of lengths from 3 – 88 m. Modal polarization data are evaluated to combine field observations with 3-D numerical models. We find outcrop-scale elastic moduli vary from 0.8 to 8.0 GPa, correlated with diagenetic processes, and identify low damping at all sites. Dense-array cross-correlation results from an additional arch validate predictions of simple bending modes and fixed boundary conditions. Our results establish use of sparse ambient resonance measurements for structural assessment and monitoring of arches and similar freestanding geologic features.
The Andes Cordillera, which runs the length of South America and rises up to 5,000 m MSL within 200 km of the Pacific coast, dramatically influences the distribution of winter precipitation and snowpack over Chile and Argentina. The study of orographic precipitation processes, particularly along the western slopes of the Andes, is important to improve forecasts of severe flooding and snowpack in a region that depends on snowmelt for water resources. While orographic effects have been investigated on synoptic scales in the Andes, the lack of operational radar coverage and high-elevation, long-term precipitation records have, before the present study, precluded an in-depth investigation into the mesoscale and microphysical processes that affect the distribution of precipitation in the region.
This dataset was collected during the Chilean Orographic and Mesoscale Precipitation Study (ChOMPS), which, from May-October 2016, investigated the evolution of precipitation amounts, dropsize distribution, and the vertical profile of radar echoes along an east-west transect that stretched from the Pacific coast to the windward slope of the Andes. The transect, at ~36°S, was made up of a coastal site upstream of the coastal mountain range (Concepción), a central valley site (Chillán), and a mountain site (Las Trancas). Instrumentation along the transect included three vertically pointing Micro-Rain-Radars, two Parsivel Disdrometers, and several meteorological stations.
The dataset documents the evolution of Doppler velocity and reflectivity profiles with inland extent during early, middle, and late storm sectors. Additionally, the transect provides a season-long record of the inland evolution of melting layer height as well as the prevalence and structure of shallow non-brightband rain and the characteristics of its inland penetration to the central valley. This dataset, the first of its kind in the Chilean Andes, provides unique insight into mesoscale and orographic precipitation processes that also have applicability to the west coast of the United States and other mountainous regions.
This SAS program can be used to calculate Grocery Purchase Quality Index-2016 (GPQI-2016) total and component scores from food purchase data (dollars and cents) that have been summarized into the 29 categories of the USDA Food Plans. The code can be adapted to calculate GPQI-2016 scores for data that use a smaller number of categories.
Background. Common cold viruses create significant health and financial burdens, and understanding key loci of transmission would help focus control strategies. This study (1) examines factors that influence when individuals transition from a negative to positive test (acquisition) or a positive to negative test (loss) of rhinovirus (HRV) and other respiratory tract viruses in 26 households followed weekly for one year, (2) investigates evidence for intrahousehold and interhousehold transmission and the characteristics of individuals implicated in transmission, and (3) builds data-based simulation models to identify factors that most strongly affect patterns of prevalence. Methods. We detected HRV, coronavirus, paramyxovirus, influenza and bocavirus with the FilmArray polymerase chain reaction (PCR) platform (BioFire Diagnostics, LLC). We used logistic regression to find covariates affecting acquisition or loss of HRV including demographic characteristics of individuals, their household, their current infection status, and prevalence within their household and across the population. We apply generalized linear mixed models to test robustness of results. Results. Acquisition of HRV was less probable in older individuals and those infected with a coronavirus, and higher with a higher proportion of other household members infected. Loss of HRV is reduced with a higher proportion of other household members infected. Within households, only children and symptomatic individuals show evidence for transmission, while between households only a higher number of infected older children (ages 5-19) increases the probability of acquisition. Coronaviruses, paramyxoviruses and bocavirus also show evidence of intrahousehold transmission. Simulations show that age-dependent susceptibility and transmission have the largest effects on mean HRV prevalence. Conclusions. Children are most likely to acquire and most likely to transmit HRV both within and between households, with infectiousness concentrated in symptomatic children. Simulations predict that the spread of HRV and other respiratory tract viruses can be reduced but not eliminated by practices within the home.
Objective: In 2018, the Network of the National Libraries of Medicine (NNLM) launched a national sponsorship program to support U.S. public library staff in completing the Medical Library Association’s (MLA) Consumer Health Information Specialization (CHIS). The primary objective of this research project was to determine if completion of the sponsored specialization was successful in improving public library staff ability to provide consumer health information and whether it resulted in new services, programming, or outreach activities at public libraries. Secondary objectives of this research were to determine motivation for and benefits of the specialization and to determine the impact on sponsorship on obtaining and continuing the specialization.
Methods: To evaluate the sponsorship program, we developed and administered a 16-question online survey via REDCap in August 2019 to 224 public library staff that were sponsored during the first year of the program. We measured confidence and competence in providing consumer health information using questions aligned with the eight Core Competencies for Providing Consumer Health Information Services [1]. Additionally, the survey included questions about new consumer health information activities at public libraries, public library staff motivation to obtain the specialization, and whether it led to immediate career gains. To determine the overall value of the NNLM sponsorship, we measured whether funding made it more likely for participants to complete or continue the specialization.
Results: Overall, 136 participants (61%) responded to the survey. Our findings indicated that the program was a success: over 80% of participants reported an increase in core consumer health competencies, with a statistically significant improvement in mean competency scores after completing the specialization. Ninety percent of participants have continued their engagement with NNLM, and over half offered new health information programs and services at their public library. All respondents indicated that completing the specialization met their expectations, but few reported immediate career gains. While over half of participants planned to renew the specialization or obtain the more advanced, Level II specialization, 72% indicated they would not continue without the NNLM sponsorship.
Conclusion: Findings indicate that NNLM sponsorship of the CHIS specialization was successful in increasing the ability of public library staff to provide health information to their community. and This dataset represents the de-identified raw results of a 16-question, online survey (via REDCap) collected in August 2019 to 224 public library staff who were sponsored for a Consumer Health Information Specialization (CHIS). The purpose of the study was to determine whether the sponsorship program had an impact on public library staff to provide consumer health information.
Using a suite of numerical calculations, we consider the long-term evolution of
circumbinary debris from the Pluto--Charon giant impact. Initially, these solids
have large eccentricity and pericenters near Charon's orbit. On time scales of
100--1000 yr, dynamical interactions with Pluto and Charon lead to the ejection
of most solids from the system. As the dynamics moves particles away from the
barycenter, collisional damping reduces the orbital eccentricity of many particles.
These solids populate a circumbinary disk in the Pluto-Charon orbital plane; a large
fraction of this material lies within a `satellite zone' that encompasses the orbits
of Styx, Nix, Kerberos, and Hydra. Compared to the narrow rings generated from the
debris of a collision between a trans-Neptunian object (TNO) and Charon,
disks produced after the giant impact are much more extended and may be a less promising option for producing small circumbinary satellites.
We analyzed 4,754 broadband seismic recordings of the SKS, SKKS, and SPdKS wavefield from 13 high quality events sampling the Samoa ultralow-velocity zone (ULVZ). We measured differential travel-times and amplitudes between the SKKS and SKS arrivals, which are highly sensitive to the emergence of the SPdKS seismic phase, which is in turn highly sensitive to lowermost mantle velocity perturbations such as generated by ULVZs. We modeled these data using a 2-D axi-symmetric waveform modeling approach and are able to explain these data with a single ULVZ. In order to predict both travel-time and amplitude perturbations we found that a large ULVZ length in the great circle arc direction on the order of 10° or larger is required. The large ULVZ length limits acceptable ULVZ elastic parameters. Here we find that δVS and δVP reductions from 20% to 22% and 15% to 17% respectively gives us the best fit, with a thickness of 26 km. Initial 3-D modeling efforts do not recover the extremes in the differential measurements, demonstrating that 3-D effects are important and must be considered in the future. However, the 3-D modeling is generally consistent with the velocity reductions recovered with the 2-D modeling. These velocity reductions are compatible with a compositional component to the ULVZ. Furthermore, geodynamic predictions for a compositional ULVZ that is moving predict a long linear shape similar to the shape of the Samoa ULVZ we confirm in this study.
and This collection includes radial component displacement seismograms in the time window including the SKS, SKKS and SPdKS seismic arrivals. These data all interact with the Samoa ultra-low velocity zone at the core-mantle boundary. All data used in the study of Krier et al., 2021 (JGR) is included in this collection.
Ground-based measurements of frozen precipitation are heavily influenced by interactions of surface winds with gauge-shield geometry. The Multi-Angle Snowflake Camera (MASC), which photographs hydrometeors in free-fall from three different angles while simultaneously measuring their fall speed, has been used in the field at multiple mid-latitude and polar locations both with and without wind shielding. Here we present an analysis of Arctic field observations — with and without a Belfort double Alter shield — and compare the results to computational fluid dynamics (CFD) simulations of the airflow and corresponding particle trajectories around the unshielded MASC. MASC-measured fall speeds compare well with Ka-band Atmospheric Radiation Measurement (ARM) Zenith Radar (KAZR) mean Doppler velocities only when winds are light (< 5 m/s) and the MASC is shielded. MASC-measured fall speeds that do not match KAZR measured velocities tend to fall below a threshold value that increases approximately linearly with wind speed but is generally < 0.5 m/s. For those events with wind speeds < 1.5 m/s, hydrometeors fall with an orientation angle mode of 12 degrees from the horizontal plane, and large, low-density aggregates are as much as five times more likely to be observed. Simulations in the absence of a wind shield show a separation of flow at the upstream side of the instrument, with an upward velocity component just above the aperture, which decreases the mean particle fall speed by 55% (74%) for a wind speed of 5 m/s (10 m/s). We conclude that accurate MASC observations of the microphysical, orientation, and fall speed characteristics of snow particles require shielding by a double wind fence and restriction of analysis to events where winds are light (< 5 m/s). Hydrometeors do not generally fall in still air, so adjustments to these properties' distributions within natural turbulence remain to be determined.
This study investigates impacts of altering subgrid-scale mixing in “convection-permitting” km-scale horizontal grid spacing (∆h) simulations by applying either constant or stochastic multiplicative factors to the horizontal mixing coefficients within the Weather Research and Forecasting model. In quasi-idealized 1-km ∆h simulations of two observationally based squall line cases, constant enhanced mixing produces larger updraft cores that are more dilute at upper levels, weakens the cold pool, rear inflow jet, and front-to-rear flow of the squall line, and degrades the model’s effective resolution. Reducing mixing by a constant multiplicative factor has the opposite effect on all metrics. Completely turning off parameterized horizontal mixing produces bulk updraft statistics and squall line mesoscale structure closest to a LES “benchmark” among all 1-km simulations, although the updraft cores are too undilute. The stochastic mixing scheme, which applies a multiplicative factor to the mixing coefficients that varies stochastically in time and space, is employed at 0.5-, 1-, and 2-km ∆h. It generally reduces mid-level vertical velocities and enhances upper-level vertical velocities compared to simulations using the standard mixing scheme, with more substantial impacts at 1-km and 2-km ∆h compared to 0.5-km. The stochastic scheme also increases updraft dilution to better agree with the LES for one case, but has less impact on the other case. Stochastic mixing acts to weaken the cold pool but without a significant impact on squall line propagation. It also does not affect the model’s overall effective resolution unlike applying constant multiplicative factors to the mixing coefficients.
We consider a scenario where the small satellites of Pluto and Charon grew within a disk of debris from an impact between Charon and a trans-Neptunian object (TNO). After Charon's orbital motion boosts the debris into a disk-like structure, rapid orbital damping of meter-sized or smaller objects is essential to prevent the subsequent reaccretion or dynamical ejection by the binary. From analytical estimates and simulations of disk evolution, we estimate an impactor radius of 30-100 km; smaller (larger) radii apply to an oblique (direct) impact. Although collisions between large TNOs and Charon are unlikely today, they were relatively common within the first 0.1-1 Gyr of the solar system. Compared to models where the small satellites agglomerate in the debris left over by the giant impact that produced the Pluto-Charon binary planet, satellite formation from a later impact on Charon avoids the destabilizing resonances that sweep past the satellites during the early orbital expansion of the binary.
Thin boundary layer Arctic mixed-phase clouds are generally thought to precipitate pristine and aggregate ice crystals. Here we present automated surface photographic measurements showing that only 35\% of precipitation particles exhibit negligible riming and that graupel particles $\geq1\,\rm{mm}$ in diameter commonly fall from clouds with liquid water paths less than $50\,\rm{g\,m^{-2}}$. A simple analytical formulation predicts that significant riming enhancement can occur in updrafts with speeds typical of Arctic clouds, and observations show that such conditions are favored by weak temperature inversions and strong radiative cooling at cloud top. However, numerical simulations suggest that a mean updraft speed of $0.75\,\rm{m\,s^{-1}}$ would need to be sustained for over one hour. Graupel can efficiently remove moisture and aerosols from the boundary layer. The causes and impacts of Arctic riming enhancement remain to be determined.
We consider a scenario where the small satellites of Pluto and Charon grew within a disk of debris from an impact between Charon and a trans-Neptunian Object (TNO). After Charon’s orbital motion boosts the debris into a disk-like structure, rapid orbital damping of meter-size or smaller objects is essential to prevent the subsequent re-accretion or dynamical ejection by the binary. From analytical estimates and simulations of disk evolution, we estimate an impactor radius of 30–100 km; smaller (larger) radii apply to an oblique (direct) impact. Although collisions between large TNOs and Charon are unlikely today, they were relatively common within the first 0.1–1 Gyr of the solar system. Compared to models where the small satellites agglomerate in the debris left over by the giant impact that produced the Pluto-Charon binary planet, satellite formation from a later impact on Charon avoids the destabilizing resonances that sweep past the satellites during the early orbital expansion of the binary.