We determined whether a large, multi-analyte panel of circulating biomarkers can improve detection of early-stage pancreatic ductal adenocarcinoma (PDAC). We defined a biologically relevant subspace of blood analytes based on previous identification in premalignant lesions or early-stage PDAC and evaluated each in pilot studies. The 31 analytes that met minimum diagnostic accuracy were measured in serum of 837 subjects (461 healthy, 194 benign pancreatic disease, 182 early stage PDAC). We used machine learning to develop classification algorithms using the relationship between subjects based on their changes across the predictors. Model performance was subsequently evaluated in an independent validation data set from 186 additional subjects.
This dataset encompasses the results of a series of controlled experiments conducted at the University of Utah's Industrial Hygiene Research Laboratory between November 2021 and November 2022. It includes data from tests assessing aerosol containment and surface contamination using the U-COVER device. The dataset details the effectiveness of different device designs (D1A, D1B, D2) in containing salt aerosols under various conditions, including with and without exhaust ventilation. Measurements were conducted using GRIMM Model 1.109 Portable Aerosol Spectrometers and analyzed for particle size distributions and concentrations. The findings provide insights into the protective capabilities of the U-COVER device in medical settings, with implications for healthcare worker safety."
This dataset covers all of the marbriers (stonecutters) listed in the commercial almanacs for the city of Paris from 1798 to 1907. The author used the almanacs available digitally on the Bibliothèque nationale de France's digital library, Gallica (gallica.bnf.fr). The dataset was initially compiled to study the development of the funerary monuments industry in Paris, although the dataset aggregates all stonemasons' enterprises and ateliers regardless of their field of specialization. Binary variables are included in the dataset, based on text descriptions in the almanacs, to indicate named areas of specialization.
Historically, the compilation of the annual commercial almanacs was a project undertaken by two different publishers (Bottin and Firmin Didot), who eventually merged in 1857. Every year, in addition to the information that had already been collected, corrections and additions were solicited from the general public. According to the notice included at the beginning of the 1838 issue, listing in the almanac was (and always had been) free. If one wanted details in addition to a general category of work to be included in a record, individuals needed to contact the editor directly (there is no mention of what this might have cost). See: Sébastien Bottin, Almanach du commerce de Paris, des départemens de la France, et des principals villes du monde (Paris, 1838); and Firmin Didot et Bottin Réunis, Annuaire et almanac du commerce, de l’industrie, de la magistrature et de l’administration (Paris: 1857).
The dataset was collected in the process of carrying out a research on the effects of photochemical aging and interactions with secondary organic aerosols on cellular toxicity of combustion particles between the year 2021 to 2022
This dataset accounts for all jobs undertaken by the Société Le Roy Bouillon, a funerary monuments company in Paris, from 1890 to 1902. The first sheet, “Activity Data” accounts for each job and the fee charged to the client for that job. It also categories each job as either a new cemetery construction, maintenance to existing cemetery structures, or other jobs unrelated to cemetery construction. The second sheet, “Outside Paris,” summarizes the annual activity, recording the number of projects undertaken within Paris versus outside of the city, new constructions versus maintenance work, and revenue coming in from each type of job. The original records are currently housed in a private collection in Paris and were manually transcribed by the author.
This dataset summarizes burial counts according to burial type (free, temporary, or perpetual) for the cemeteries of Père-Lachaise, Montmartre, and Montparnasse in Paris. The data covers the period of 1804 to 1840 and was derived from the digitized daily records of burial for the city of Paris, which are currently held in the Archives de Paris. See Registres journaliers d'inhumation https://archives.paris.fr/r/216/cimetieres). These data are organized by the number of each burial type recorded per page of the digitized records.
The data was obtained from the FDTD simulations. For one of the FDTD simulations, the conductivity data for British Columbia was used in order to obtain the simulated data. The data obtained from simulations are post-processed using MATLAB for plotting the figures in the paper.
The COVID-19 pandemic disrupted scientific research, teaching, and learning in higher education and forced many institutions to explore new modalities in response to the abrupt shift to remote learning. Accordingly, many colleges and universities struggled to provide the training, technology, and best practices to support faculty and students, especially those at historically disadvantaged and underrepresented institutions. In this study we investigate different remote learning modalities to improve and enhance research education training for faculty and students. We specifically focus on Responsible and Ethical Conduct of Research (RECR) and Research Mentoring content to help address the newly established requirements of the National Science Foundation for investigators. To address this need we conducted a workshop to determine the effectiveness of three common research education modalities: Live Lecture, Podcast, and Reading. The Live Lecture sessions provided the most evidence of learning based on the comparison between pre- and post-test results, whereas the Podcast format was well received but produced a slight (and non-significant) decline in scores between the pre- and post-tests. The Reading format showed no significant improvement in learning. The results of our workshop illuminate the effectiveness and obstacles associated with various remote learning modalities, enabling us to pinpoint areas that require additional refinement and effort, including the addition of interactive media in Reading materials.
The purpose of this derived dataset was to analyze menstrual cycle lengths in relation to lunar calendar. This datafile of start and end date of 3324 menstrual cycles of 581 women is part of a combined dataset of three cohorts of heterosexually active women who received instruction in the Creighton Model FertilityCare System (CrM) through centres across the United States and Canada. The CrM has standardised protocols for teaching women how to observe, record, and interpret daily vaginal discharge from bleeding and cervical fluid on a daily diary, called a CrM chart, and to use these standardised observations to identify the estimated time of ovulation and days when intercourse is likely to result in pregnancy. The cohorts included: "Creighton Model Effectiveness, Intentions, and Behaviours Assessment" (CEIBA) (2009–2013), a prospective cohort of women without known subfertility, aimed to evaluate and classify pregnancy rates and pregnancy intentions during use of the CrM; "Creighton Model MultiCenter Fecundability Study" (CMFS) (1990–1996), a retrospective cohort of presumably fertile and subfertile women using CrM, aimed to assess the relationship between vulvar mucus observations and the day and cycle-specific probabilities of conception; and "Time to Pregnancy in Normal Fertility" (TTP) (2003–2006), a parallel-randomised trial, which aimed to assess the impact of CrM use on time to pregnancy in couples of proven fertility trying to conceive. Each of the cohorts aimed to include heterosexually active couples with normal fecundity. Eligibility criteria were assessed by women's responses to the CrM general intake form and/or a screening questionnaire. Eligibility requirements in the original studies included women, age 18–40 years old (upper limit of 35 years for TTP), not pregnant at entry, having regular menstrual bleeding, and not breast feeding (CMFS and TTP), or if breast feeding, not doing so exclusively (CEIBA). Recent users of oral contraceptives had to have at least one menstrual bleed (CEIBA) or two menstrual bleeds (TTP) since stopping the oral contraceptives; however, for CMFS there was no restriction for time since discontinuing oral contraceptives. All studies also required normal menstrual patterns since last use of depo-medroxy-progesterone acetate or a hormonal intra-uterine device.