Search Constraints

You searched for: Publisher The Hive: University of Utah Data Repository Remove constraint Publisher: The Hive: University of Utah Data Repository Resource Type Dataset Remove constraint Resource Type: Dataset

Search Results

  1. Data for: Restitution Characteristics of His Bundle and Working Myocardium in Isolated Rabbit Hearts

    Work
    Description: The Purkinje system (PS) and the His bundle have been recently implicated as an important driver of the rapid activation rate after 1-2 minutes of ventricular fibrillation (VF). It is unknown whether activations during VF propagate through the His-Purkinje system to other portions of the the working myocardium (WM). Little is known about restitution characteristic differences between the His bundle and working myocardium at short cycle lengths. In this study, rabbit hearts (n=9) were isolated, Langendorff- perfused, and electromechanically uncoupled with blebbistatin (10 μM). Pacing pulses were delivered directly to the His bundle. By using standard glass microelectrodes, action potentials duration (APD) from the His bundle and WM were obtained simultaneously over a wide range of stimulation cycle lengths (CL). The global F-test indicated that the two restitution curves of the His bundle and the WM are statistically significantly different (P<0.05). Also, the APD of the His bundle was significantly shorter than that of WM throughout the whole pacing course (P<0.001). The CL at which alternans developed in the His bundle vs. the WM were shorter for the His bundle (134.2±13.1ms vs. 148.3±13.3ms, P<0.01) and 2:1 block developed at a shorter CL in the His bundle than in WM (130.0±10.0 vs. 145.6±14.2ms, P<0.01). The His bundle APD was significantly shorter than that of WM under both slow and rapid pacing rates, which suggest that there may be an excitable gap during VF and that the His bundle may conduct wavefronts from one bundle branch to the other at short cycle lengths and during VF.
    Keyword: action potential duration, cardiology, microelectrode, His bundle, alternans, working myocardium, rabbit, ventricular fibrillation, and restitution curve
    Creator: Hu, Nan, Huang, Shangwei, Ranjan, Ravi, Panitchob, Nuttanont, Huang, Liqun, and Dosdall, Derek
    Owner: Nuttanont Panitchob
    Publisher: The Hive: University of Utah Data Repository
    Location: Salt Lake City, UT
    Date Uploaded: 10/12/2017
    Date Modified: 10/25/2018
    Date Created: 20160321 to 20160525
    Rights: CCO – As the data author, you are choosing to place your data into the public domain.
    Resource Type: Dataset
    Identifier: https://doi.org/10.7278/S50R9MJX
    Contact Email: Derek.Dosdall@utah.edu
    Funders: National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health
  2. Pharmacokinetics of Locally Delivered Vancomycin to Bone

    Work
    Description: Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin. Additionally, we were able to inhibit the development of osteomyelitis in the tibia if the treatment was administered locally at the same time as a bacterial inoculum (i.e., Log10 7.82 CFU/mL or 6.62x107 CFU/mL), when compared to an untreated group. These findings suggest that local intramedullary vancomycin delivery can achieve sufficiently high local concentrations to prevent development of osteomyelitis while minimizing systemic toxicity.
    Keyword: antibiotics, pharmacokinetics, bone, and infections
    Subject: Infectious Diseases
    Creator: Loc-Carrillo, Catherine
    Contributor: Burr, Michael, Wu, Sijia, Churchill, John, Wang, Caroline, Hoerger, Kelly, Canden, Ahranee, Agarwal, Jay, Fernandez, Sheena, and Fredricksen, Hunter
    Owner: Catherine Loc Carrillo
    Publisher: The Hive: University of Utah Data Repository
    Location: Salt Lake City, UT
    Language: English
    Date Uploaded: 08/17/2017
    Date Modified: 08/07/2018
    Date Created: 20130501 - 20150130
    Rights: CC BY NC - Allows others to use and share your data non-commercially and with attribution.
    Resource Type: Dataset
    Identifier: https://doi.org/10.7278/S5W0942B
    Contact Email: c.loc.carrillo@hsc.utah.edu
    Funders: University of Utah Research Foundation